Compulsive behavior in Prader-Willi syndrome: Examining severity in early childhood
Compulsive behavior in Prader-Willi syndrome: Examining severity in early childhood
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DOI：
10.1016/j.ridd.2005.01.002
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发表时间：
2006-03-01
影响因子：
3.1
通讯作者：
Thompson, T
中科院分区：
文献类型：
--
作者：
Dimitropoulos, A;Blackford, J;Thompson, T
Prader-Willi综合征(PWS)是一种遗传性疾病，以过度吞噬和对食物的关注为特征。研究人员指出，患有PWS的人，包括年幼的儿童，表现出与食物有关的强迫症和与食物无关的强迫症。规范的仪式也经常出现在典型的发育中的学龄前儿童中。然而，目前还不清楚这些行为是如何影响孩子的。尽管与其他人群相比，患有PWS的学龄前儿童表现出更多的仪式类型，但这些行为的严重程度是否与规范发展过程中经历的仪式不同尚不确定。因此，这项研究的目的是确定患有PWS的学龄前儿童表现出的仪式性行为是否与正常发展期间表现出的仪式性行为的严重程度不同。我们还试图确定非食物仪式行为是否与PWS的过度吞噬有关。68名PWS儿童、86名发育正常儿童和57名发育迟缓儿童的父母完成了关于仪式和饮食行为的问卷调查。患有PWS的儿童表现出比一般发育迟缓儿童更严重的仪式性行为，但其他发育迟缓儿童则没有。然而，在PWS中，与食物无关的仪式的严重程度与饮食行为的严重程度有关。我们假设，吞噬过多和非食物相关的强迫症之间的这种联系可能共享一个共同的潜在神经生物学机制。(C)2005爱思唯尔有限公司。保留所有权利。
Prader-Willi syndrome (PWS) is a genetic disorder characterized by hyperphagia and food preoccupations. Researchers indicate that individuals with PWS, including young children, exhibit food and non-food-related compulsions. Normative rituals are also often present among typically developing preschoolers. However, it is unclear how these behaviors affect the child. Although preschoolers with PWS exhibit more types of rituals than other populations, it is uncertain if the severity of these behaviors differs from the rituals experienced during normative development. Thus, the purpose of this research was to determine whether the ritualistic behaviors exhibited by preschoolers with PWS differ in severity from those exhibited during normative development. We also sought to identify whether non-food ritualistic behavior was related to the hyperphagia in PWS. Parents of 68 children with PWS, 86 typically developing children, and 57 children with developmental delays completed questionnaires on rituals and eating behavior. Children with PWS exhibited more severe ritualistic behavior than typically developing children but not other children with developmental delays. However, the severity of non-food-related rituals was related to the severity of eating behavior in PWS. We hypothesize that this link between hyperphagia and non-food-related compulsivity may share a common underlying neurobiological mechanism. (c) 2005 Elsevier Ltd. All rights reserved.