The impact of 4D-Flow MRI spatial resolution on patient-specific CFD simulations of the thoracic aorta.
The impact of 4D-Flow MRI spatial resolution on patient-specific CFD simulations of the thoracic aorta.
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DOI：
10.1038/s41598-022-19347-6
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发表时间：
2022-09-06
影响因子：
4.6
通讯作者：
Bissell, Malenka
中科院分区：
文献类型：
--
作者：
Cherry, Molly;Khatir, Zinedine;Khan, Amirul;Bissell, Malenka
磁共振成像 (MRI) 被认为是医学成像技术的黄金标准，因为它可以对血管进行精确成像。 4 维血流磁共振成像 (4D-Flow MRI) 建立在传统 MRI 的基础上，提供三个矢量方向的血流数据和时间分辨震级数据集。因此，它可用于回顾性计算感兴趣的血液动力学参数，例如壁剪应力 (WSS)。然而，多项研究表明，成像技术的一个重大限制是目前可用的时空分辨率。最近的进展提出并成功地将 4D 流 MRI 成像技术与计算流体动力学 (CFD) 集成，以生成针对患者的特定模拟，有可能帮助治疗、手术决策和风险分层。然而，目前尚不清楚在任何特定于患者的 CFD 模拟中使用不足的 4D-Flow MRI 空间分辨率的后果，尽管这是一个公认的限制。本研究中提出的研究旨在量化基于患者特定 4D-Flow MRI 的 CFD 模拟的不准确性，这些不准确性可归因于采集 4D-Flow MRI 数据时空间分辨率不足。在这项研究中，患者接受了四次以不同各向同性空间分辨率采集的 4D-Flow MRI 扫描，随后使用每次扫描产生的几何和速度数据运行特定于患者的 CFD 模拟。结果发现，与基于 的 CFD 模拟相比，使用 的空间分辨率大大低估了收缩期峰值时的最大速度幅度。研究了 4D-Flow MRI 空间分辨率对 CFD 模拟计算出的 WSS 的影响，结果表明，基于粗略 4D-Flow MRI 空间分辨率的 CFD 模拟中 WSS 被低估。作者得出的结论是，在采集 4D-Flow MRI 数据以执行患者特定的 CFD 模拟时，必须使用最低 4D-Flow MRI 空间分辨率。较粗的空间分辨率将在流场和几何形状内产生显着差异。
Magnetic Resonance Imaging (MRI) is considered the gold standard of medical imaging technologies as it allows for accurate imaging of blood vessels. 4-Dimensional Flow Magnetic Resonance Imaging (4D-Flow MRI) is built on conventional MRI, and provides flow data in the three vector directions and a time resolved magnitude data set. As such it can be used to retrospectively calculate haemodynamic parameters of interest, such as Wall Shear Stress (WSS). However, multiple studies have indicated that a significant limitation of the imaging technique is the spatiotemporal resolution that is currently available. Recent advances have proposed and successfully integrated 4D-Flow MRI imaging techniques with Computational Fluid Dynamics (CFD) to produce patient-specific simulations that have the potential to aid in treatments,surgical decision making, and risk stratification. However, the consequences of using insufficient 4D-Flow MRI spatial resolutions on any patient-specific CFD simulations is currently unclear, despite being a recognised limitation. The research presented in this study aims to quantify the inaccuracies in patient-specific 4D-Flow MRI based CFD simulations that can be attributed to insufficient spatial resolutions when acquiring 4D-Flow MRI data. For this research, a patient has undergone four 4D-Flow MRI scans acquired at various isotropic spatial resolutions and patient-specific CFD simulations have subsequently been run using geometry and velocity data produced from each scan. It was found that compared to CFD simulations based on a , using a spatial resolution of substantially underestimated the maximum velocity magnitude at peak systole by . The impacts of 4D-Flow MRI spatial resolution on WSS calculated from CFD simulations have been investigated and it has been shown that WSS is underestimated in CFD simulations that are based on a coarse 4D-Flow MRI spatial resolution. The authors have concluded that a minimum 4D-Flow MRI spatial resolution of must be used when acquiring 4D-Flow MRI data to perform patient-specific CFD simulations. A coarser spatial resolution will produce substantial differences within the flow field and geometry.
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