IDENTIFICATION OF INTERNEURONS WITH CONTRALATERAL, CAUDAL AXONS IN THE LAMPREY SPINAL-CORD - SYNAPTIC-INTERACTIONS AND MORPHOLOGY
IDENTIFICATION OF INTERNEURONS WITH CONTRALATERAL, CAUDAL AXONS IN THE LAMPREY SPINAL-CORD - SYNAPTIC-INTERACTIONS AND MORPHOLOGY
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DOI：
10.1152/jn.1982.47.5.961
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发表时间：
1982-01-01
影响因子：
2.5
通讯作者：
BUCHANAN, JT
中科院分区：
文献类型：
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作者：
BUCHANAN, JT
用细胞内记录法研究了七鳃鳗脊髓本体中间神经元（CC中间神经元）的轴突投射对侧和尾侧。CC中间神经元通过在细胞内刺激细胞体期间记录它们在脊髓中的细胞外轴突尖峰来鉴定。CC中间神经元的轴突投射证实后，细胞内注射和辣根过氧化物酶的发展。CC中间神经元的细胞内刺激在肌节运动神经元、外侧中间神经元和其他位于脊髓尾侧的CC中间神经元中产生突触电位。CC中间神经元大多数为抑制性，但也有部分为兴奋性。根据网状脊髓Mueller细胞的输入，CC中间神经元分为3类（CC 1，CC 2和CC 3）。同侧Mueller细胞B1和对侧Mauthner细胞均可兴奋CC 1中间神经元。CC 1中间神经元呈抑制性。CC 2中间神经元也是抑制性的，但是它们通过来自同侧Mueller细胞B2-4的兴奋而与CC 1中间神经元区分开。CC 3中间神经元是兴奋性的，被同侧Mueller细胞I1抑制。抑制CC中间神经元可能是重要的运动协调七鳃鳗。七鳃鳗身体在反射和游泳过程中的运动包括身体两侧肌节肌肉的收缩和放松。通过与同侧肌节运动神经元共同活动，自律CC中间神经元可以在这些运动过程中抑制对侧运动神经元。
Propriospinal interneurons with axons projecting contralaterally and caudally (CC interneurons) were studied with intracellular recordings in the lamprey. CC interneurons were identified by recording their axon spikes extracellularly in the spinal cord during intracellular stimulation of the cell body. The axon projections of CC interneurons were confirmed after intracellular injection and development of horseradish peroxidase. Intracellular stimulation of CC interneurons produced synaptic potentials in myotomal motoneurons, lateral interneurons and other CC interneurons that lay caudally on the opposite side of the spinal cord. Most CC interneurons were inhibitory, but some were excitatory. CC interneurons were divided into 3 classes (CC1, CC2 and CC3) on the basis of reticulospinal Mueller cell inputs. CC1 interneurons were excited by the ipsilateral Mueller cell B1 and the contralateral Mauthner cell. CC1 interneurons were inhibitory. CC2 interneurons were also inhibitory, but they were distinguished from CC1 interneurons by their excitation from the ipsilateral Mueller cells B2-4. CC3 interneurons were excitatory and were inhibited by the ipsilateral Mueller cell I1. Inhibitory CC interneurons may be important for motor coordination in the lamprey. Movements of the lamprey body during reflexes and swimming consist of contraction and relaxation of myotomal muscles on opposite sides of the body. By being coactive with ipsilateral myotomal motoneurons, inhibtory CC interneurons could contribute to the inhibition of contralateral motoneurons during these movements.