Spatial correlation between traversal and cellular response in ion radiotherapy - Towards single track spectroscopy
Spatial correlation between traversal and cellular response in ion radiotherapy - Towards single track spectroscopy
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DOI：
10.1016/j.radmeas.2013.01.060
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发表时间：
2013-09-01
影响因子：
2
通讯作者：
Greilich, S.
中科院分区：
文献类型：
--
作者：
Niklas, M.;Melzig, C.;Greilich, S.
关于离子癌束治疗和空间研究中物理能量沉积和生物反应之间的联系机制的知识仍然有限。我们试图开发一种基于荧光核径迹检测器（FNTD）的新型检测器系统，该检测器覆盖有可行的细胞层，以获得微米尺度的离子穿越和细胞损伤之间的空间相关性。除了轨道位置之外，我们还研究了通过 FNTD 读数从单个粒子轨道获得离子类型和能量信息的可能性。为了访问这两个参数，我们的目标是找到入射离子的局部能量转移 (LET) 和探测器材料中最大二次电子射程的替代值，因为这些量与离子类型和能量相关。我们通过最大强度信号和半峰全宽 (FWHM) 参数化单个离子荧光信号的强度分布。第一个似乎是入射粒子 LET 的合适替代品，而后者只是探测器材料中最大二次电子范围的有限测量。 (c) 2013 Elsevier Ltd. 保留所有权利。
Knowledge about the mechanisms linking physical energy deposition and biological response in ion cancer beam therapy and space research is still limited. We sought to develop a novel detector system based on fluorescent nuclear track detector (FNTD) covered with a viable cell-layer to gain spatial correlation between ion traversal and cellular damage on a mu m scale. We investigated the possibility to gain, in addition to track location, information on ion type and energy from a single particle track by the FNTD read-out. To access both parameters we aimed to find surrogates for the local energy transfer (LET) of the incident ion and the maximum secondary electron range in the detector material as those quantities are related to the ion type and energy. We parametrized the intensity profile of the fluorescent signal of a single ion by the maximum intensity signal and full width half maximum (FWHM). The first seems to be a suitable surrogate for the LET of the incident particle whereas the latter is only a limited measure for the maximum secondary electron range in detector material. (c) 2013 Elsevier Ltd. All rights reserved.