Corneal transplantation—immunologically privileged status
Corneal transplantation—immunologically privileged status
复制标题
角膜移植——免疫特权状态
作者：
M. Katami
尽管角膜移植的成功率相对较高，而且有“免疫特权部位”的说法，但已知角膜移植可引起同种异体移植排斥反应。这在大鼠中尤其如此，在这种情况下，某些菌株组合的原位穿透性角膜移植即使在无血管床上移植也会被排斥。可靠的显微外科技术，近亲或同基因菌株的出现，以及对其主要组织相容性复合体(MHC)和免疫系统的普遍了解的迅速发展，使大鼠成为研究角膜移植后免疫学事件的主要物种。讨论的主题包括大鼠MHC(RT1)抗原及其在角膜中的分布；在完全同种异体菌株组合中不同的反应者状态，包括多种非MHC抗原的重要性；以及抗原提呈细胞(APC)在角膜移植排斥反应中的作用。
Despite the relatively high success rate and the word ‘immunologically privileged site’, it has been known that a corneal graft can induce an allograft rejection reaction. This is especially true in the rat where orthotopic penetrating corneal grafts in certain strain combinations are rejected even when transplanted in avascular bed. Reliable microsurgical techniques, together with the availability of inbred or con-genic strains and a rapidly developing knowledge of its major histocompatibility complex (MHC) and immune system in general, have made the rat a prime species in which to study the immunological events after corneal grafting.This review describes recent progress in understanding the immunological mechanisms behind corneal graft rejection. The topics discussed include the rat MHC (RT1) antigens and their distribution in the cornea; different responder status in fully allogeneic strain combinations, including the importance of multiple non-MHC antigens; and the role of antigen-presenting cells (APCs) in corneal graft rejection.
大鼠主要组织相容性复合体中第二类 I 基因座的识别和定位。
DOI：
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发表时间：
1982
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Kunz,HW;Gill3rd,TJ;Misra,DN
通讯作者：
Misra,DN