The effects of an extensive exercise programme on the progression of Mild Cognitive Impairment (MCI): study protocol for a randomised controlled trial.
The effects of an extensive exercise programme on the progression of Mild Cognitive Impairment (MCI): study protocol for a randomised controlled trial.
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DOI：
10.1186/s12877-017-0457-9
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发表时间：
2017-03-22
期刊：
影响因子：
4.1
通讯作者：
NeuroExercise Study Group
中科院分区：
文献类型：
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作者：
Devenney KE;Sanders ML;Lawlor B;Olde Rikkert MGM;Schneider S;NeuroExercise Study Group
近年来，预防痴呆症和延缓认知能力下降的运动干预获得了相当大的关注。人类和动物研究表明，定期的身体活动通过增加认知储备来靶向大脑功能。还有证据表明，运动引起的结构变化可以预防或延缓神经退行性疾病的发生。虽然最初的研究表明，轻度认知障碍（MCI）患者在运动干预后的认知能力增强，但人们对广泛的、有控制的和有规律的运动方案对MCI患者神经病理学的影响知之甚少。本研究旨在确定广泛的运动计划对MCI进展的影响。这项随机对照临床干预研究将在三个欧洲研究中心进行。每个研究中心将招募75名临床诊断为MCI的既往久坐患者。参与者将被随机分配到三组之一。一组将接受标准化的1年广泛有氧运动干预（3个单位，45分钟/周）。第二组将完成拉伸和调色（非有氧）运动（3个单位，45分钟/周），第三组将作为对照组。将在基线（T0）、6个月后（T1）和12个月后（T2）测量所有结局的变化。将通过神经心理学成套测试（CogState成套测试、连线测试和言语流畅性）确定主要结局（认知表现）。次要结果包括蒙特利尔认知评估（莫卡），心血管健康，身体活动，大脑结构变化，生活质量测量和脆弱性测量。此外，结果变量将与神经发生相关基因的遗传变异和运动干预计划引起的这些基因的表观遗传变化有关。研究结果将为运动可能减缓MCI认知能力下降速度的流行观点提供新的见解。ClinicalTrials.gov www.example.com
Exercise interventions to prevent dementia and delay cognitive decline have gained considerable attention in recent years. Human and animal studies have demonstrated that regular physical activity targets brain function by increasing cognitive reserve. There is also evidence of structural changes caused by exercise in preventing or delaying the genesis of neurodegeneration. Although initial studies indicate enhanced cognitive performance in patients with mild cognitive impairment (MCI) following an exercise intervention, little is known about the effect of an extensive, controlled and regular exercise regimen on the neuropathology of patients with MCI. This study aims to determine the effects of an extensive exercise programme on the progression of MCI. This randomised controlled clinical intervention study will take place across three European sites. Seventy-five previously sedentary patients with a clinical diagnosis of MCI will be recruited at each site. Participants will be randomised to one of three groups. One group will receive a standardised 1-year extensive aerobic exercise intervention (3 units of 45 min/week). The second group will complete stretching and toning (non-aerobic) exercise (3 units of 45 min/week) and the third group will act as the control group. Change in all outcomes will be measured at baseline (T0), after six months (T1) and after 12 months (T2). The primary outcome, cognitive performance, will be determined by a neuropsychological test battery (CogState battery, Trail Making Test and Verbal fluency). Secondary outcomes include Montreal Cognitive Assessment (MoCA), cardiovascular fitness, physical activity, structural changes of the brain, quality of life measures and measures of frailty. Furthermore, outcome variables will be related to genetic variations on genes related to neurogenesis and epigenetic changes in these genes caused by the exercise intervention programme. The results will add new insights into the prevailing notion that exercise may slow the rate of cognitive decline in MCI. ClinicalTrials.gov NCT02913053