Effects of developmental lead exposure on inhibitory avoidance learning and glutamate receptors in rats
Effects of developmental lead exposure on inhibitory avoidance learning and glutamate receptors in rats
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DOI：
10.1016/s1382-6689(01)00067-9
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发表时间：
2001-03-01
影响因子：
4.3
通讯作者：
Ho, IK
中科院分区：
文献类型：
--
作者：
Chen, HH;Ma, TG;Ho, IK
众所周知，发育过程中长期接触铅 (Pb) 会导致学习障碍。 AMPA 和 NMDA 受体已被证明参与某些形式的学习和记忆的突触机制。我们研究了 Pb 对 AMPA 和 NMDA 受体的影响是否与 Pb 引起的学习和记忆障碍有关。不同发育阶段的大鼠暴露于0.2%醋酸铅，包括母体暴露组（包括妊娠期和哺乳期）、断奶后暴露组和持续暴露组。在所有治疗组中，铅治疗都会损害学习获得，但不会损害递减回避学习任务中的记忆保留。与行为数据并行，脑切片的放射自显影分析表明，在所有三个铅暴露组中，海马 CA1 和齿状回以及内嗅皮层的 [H-3]AMPA 结合减少。然而，在连续暴露于铅的大鼠中，仅在海马 CA1 区观察到 [H-3]MK801 结合增加。研究结果表明，AMPA 受体的改变可能导致 Pb 诱导的抑制性回避学习习得缺陷。 (C) 2001 Elsevier Science B.V. 保留所有权利。
Chronic lead (Pb) exposure during development is known to produce learning deficits. AMPA and NMDA receptors have been shown to participate in the synaptic mechanisms involved in certain forms of learning and memory. We investigated whether the effects of Pb on AMPA and NMDA receptors are associated with Pb-induced impairment in learning and memory. Rats were exposed to 0.2% lead acetate at different developmental stages including a maternally exposed group (including gestation and lactation period), a postweaning exposed group, and a continuously exposed group. Lead treatment impaired learning acquisition, but not memory retention in step-down avoidance learning task in all treatment groups. In parallel with the behavioral data, autoradiographic analyses of brain sections indicated that the [H-3]AMPA binding was decreased in the CA1 and dentate gyrus of the hippocampus and entorhinal cortex in all three Pb-exposed groups. However, an increase in [H-3]MK801 binding was only observed in CA1 of the hippocampus in the continuously Pb-exposed rats. The findings suggest that alterations in AMPA receptor may contribute to the Pb-induced deficits in learning acquisition of inhibitory avoidance. (C) 2001 Elsevier Science B.V. All rights reserved.