The apolipoprotein E epsilon 4 allele is associated with increased neuritic plaques and cerebral amyloid angiopathy in Alzheimer's disease and Lewy body variant
The apolipoprotein E epsilon 4 allele is associated with increased neuritic plaques and cerebral amyloid angiopathy in Alzheimer's disease and Lewy body variant
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DOI：
10.1212/wnl.47.1.190
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发表时间：
1996-07-01
期刊：
影响因子：
9.9
通讯作者：
Thal, LJ
中科院分区：
文献类型：
--
作者：
Olichney, JM;Hansen, LA;Thal, LJ
目的：探讨载脂蛋白E （apoE）基因型与阿尔茨海默病（AD）和路易体变异（LBV）神经病变的关系。设计：AD和LBV病例的回顾性遗传神经病理学研究。主要的神经病理结果测量以载脂蛋白e基因型、神经病理诊断和性别的功能为模型。死亡年龄和症状持续时间由ANCOVA控制。患者：神经病理学诊断为AD（84例）或LBV（43例）的127例。主要结局指标：神经斑块（NPs）、神经原纤维缠结（nft）、脑淀粉样血管病（CAA）严重程度和CAA患病率的定量评分在四个脑区域：额叶中、顶叶下、颞上和海马中平均。结果：apoE epsilon 4等位基因与AD和LBV患者NPs增加有关。在AD和LBV合并组和LBV单独组中，epsilon 4等位基因与CAA频率增加有关。虽然当AD和LBV合并时，epsilon 4/4纯合子病例的CAA严重程度和nft增加，但单独使用AD或LBV时没有显著影响。结论：在AD和LBV中，apoE ε 4等位基因与NPs增加密切相关，但与新皮质nft无关。
Objective: To determine the relationship between apolipoprotein E (apoE) genotype and neuropathologic lesions in Alzheimer's disease (AD) and Lewy body variant (LBV). Design: Retrospective genetic-neuropathologic study of AD and LBV cases. The main neuropathologic outcome measures were modeled as a function of apoE genotype, neuropathologic diagnosis, and gender. Age at death and duration of symptom effects were controlled for by ANCOVA. Patients: One hundred twenty-seven cases with neuropathologically diagnosed AD (n = 84) or LBV (n = 43). Main outcome measures: Quantitative scores of neuritic plaques (NPs), neurofibrillary tangles (NFTs), cerebral amyloid angiopathy (CAA) severity, and CAA prevalence were averaged across four brain regions: midfrontal, inferior parietal, superior temporal, and hippocampal. Results: The apoE epsilon 4 allele was associated with increased NPs within both AD and LBV. The epsilon 4 allele was associated with an increased frequency of CAA in the AD and LBV groups combined and in LBV alone. While CAA severity and NFTs were increased in the epsilon 4/4 homozygous cases when AD and LBV were combined, there were no significant effects within AD or LBV alone. Conclusions: The apoE epsilon 4 allele is strongly associated with increased NPs, but not neocortical NFTs, in both AD and LBV.