IL-1β-mediated signals preferentially drive conversion of regulatory T cells but not conventional T cells into IL-17-producing cells.
IL-1β-mediated signals preferentially drive conversion of regulatory T cells but not conventional T cells into IL-17-producing cells.
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DOI：
10.4049/jimmunol.1001536
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发表时间：
2010-10-01
期刊：
影响因子：
--
通讯作者：
Boussiotis VA
中科院分区：
文献类型：
--
作者：
Li L;Kim J;Boussiotis VA
调节性T细胞（Tcells）致力于抑制功能。近年来，研究发现Tcl 4在促炎、极化条件下可产生IL-17，我们研究了Tcl 4在无外源性细胞因子和损伤条件下对IL-17产生的作用。使用体外和体内方法，我们确定在中性条件下，在APC存在下同时激活Tcl 3和初始CD 4+常规T细胞导致Tcl 3转化为产生IL-17的细胞，并且内源性IL-1β在该过程中是强制性的。机制分析表明，IL-1 R1在Tcells上高度表达，IL-1β诱导参与IL-17产生的p38和JNK的显著活化。这些观察结果可能对使用TdR的治疗策略具有重要意义。
Regulatory T cells (Tregs) are committed to suppressive functions. Recently, it was proposed that Tregs could produce IL-17 under proinflammatory, polarizing conditions.We studied the role of Tregs on IL-17 production in the absence of exogenous cytokines and insults. Using in vitro and in vivo approaches, we determined that under neutral conditions, simultaneous activation of Tregs and naive CD4+ conventional T cells in the presence of APCs resulted in conversion of Tregs into IL-17–producing cells, and endogenous IL-1β was mandatory in this process. Mechanistic analysis revealed that the IL-1R1 was highly expressed on Tregs and that IL-1β induced marked activation of p38 and JNK, which were involved in IL-17 production. These observations could have important implications on therapeutic strategies using Tregs.
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影响因子：
64.5
作者：
Ivanov, Ivaylo I.;McKenzie, Brent S.;Littman, Dan R.
通讯作者：
Littman, Dan R.
DOI：
10.1073/pnas.251194298
发表时间：
2001-11-20
影响因子：
11.1
作者：
Bennett, BL;Sasaki, DT;Anderson, DW
通讯作者：
Anderson, DW
影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK
DOI：
10.1111/j.1600-6143.2008.02533.x
发表时间：
2009-03
期刊：
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
影响因子：
--
作者：
O'Shaughnessy MJ;Vogtenhuber C;Sun K;Sitcheran R;Baldwin AS;Murphy WJ;Dang L;Jaffee B;Palmer E;Serody JS;Blazar BR
通讯作者：
Blazar BR
影响因子：
5.4
作者：
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