B Cells Carrying Antigen Receptors Against Microbes as Tools for Vaccine Discovery and Design.
B Cells Carrying Antigen Receptors Against Microbes as Tools for Vaccine Discovery and Design.
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携带抗微生物抗原受体的 B 细胞作为疫苗发现和设计的工具。
DOI：
10.1007/82_2019_156
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发表时间：
2020
影响因子：
--
通讯作者：
Nemazee,David
中科院分区：
文献类型：
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作者：
Bhullar,Deepika;Nemazee,David
基础科学能改进疫苗学的艺术吗？在这里，我们回顾了理解免疫反应的努力，目的是改进疫苗设计，并最终使用转化的B细胞和携带带有感兴趣微生物特异性抗原受体的B细胞的靶向转基因小鼠的工具来预测人类候选疫苗的疗效。
Can basic science improve the art of vaccinology? Here, we review efforts to understand immune responses with the aim to improve vaccine design and, eventually, to predict the efficacy of human vaccine candidates using the tools of transformed B cells and targeted transgenic mice carrying B cells with antigen receptors specific for microbes of interest.