Reproductive steroids and ADHD symptoms across the menstrual cycle
Reproductive steroids and ADHD symptoms across the menstrual cycle
复制标题
DOI：
10.1016/j.psyneuen.2017.11.015
复制
发表时间：
2018-02-01
影响因子：
3.7
通讯作者：
Martel, Michelle M.
中科院分区：
文献类型：
--
作者：
Roberts, Bethan;Eisenlohr-Moul, Tory;Martel, Michelle M.
虽然注意力缺陷多动障碍（ADHD）男性占优势，女性显着受损，并表现出额外的共病障碍在青春期。然而，还没有实证研究考察周期性波动的类固醇对女性多动症症状的影响。本研究探讨了雌二醇（E2），孕酮（P4），睾酮（T）与ADHD症状在整个月经周期定期骑自行车的年轻女性（N = 32），检查特质冲动作为一个主持人。女性完成了特质冲动的基线测量，每天早上提供唾液样本，每天晚上完成ADHD症状检查表，持续35天。结果表明，在P4或T水平升高的情况下，E2水平降低与第二天ADHD症状升高相关，特别是对于那些具有高特质冲动的人。阶段分析表明，无论是早期卵泡和早期黄体，或排卵后，ADHD症状的增加。因此，ADHD症状可能会随着月经周期的变化而变化，以响应内源性类固醇的变化。
Although Attention-Deficit/Hyperactivity Disorder shows (ADHD) male predominance, females are significantly impaired and exhibit additional comorbid disorders during adolescence. However, no empirical work has examined the influence of cyclical fluctuating steroids on ADHD symptoms in women. The present study examined estradiol (E2), progesterone (P4), and testosterone (T) associations with ADHD symptoms across the menstrual cycle in regularly-cycling young women (N = 32), examining trait impulsivity as a moderator. Women completed a baseline measure of trait impulsivity, provided saliva samples each morning, and completed an ADHD symptom checklist every evening for 35 days. Results indicated decreased levels of E2 in the context of increased levels of either P4 or T was associated with higher ADHD symptoms on the following day, particularly for those with high trait impulsivity. Phase analyses suggested both an early follicular and early luteal, or post-ovulatory, increase in ADHD symptoms. Therefore, ADHD symptoms may change across the menstrual cycle in response to endogenous steroid changes.