Inverse Association of Plasma Vanadium Levels With Newly Diagnosed Type 2 Diabetes in a Chinese Population
Inverse Association of Plasma Vanadium Levels With Newly Diagnosed Type 2 Diabetes in a Chinese Population
复制标题
中国人群血浆钒水平与新诊断 2 型糖尿病的负相关
DOI：
10.1093/aje/kwu148
复制
发表时间：
2014-08-15
影响因子：
5
通讯作者：
Liu, Liegang
中科院分区：
文献类型：
--
作者：
Wang, Xia;Sun, Taoping;Liu, Liegang
已提出钒酸盐化合物对2型糖尿病的发病机制和并发症具有有益作用。我们的目的是评估血浆钒水平与2型糖尿病之间的关系。我们进行了一项病例对照研究，包括1，598名中国受试者，有或没有新诊断的2型糖尿病（2004年12月至2007年12月）。病例组和对照组按年龄和性别进行频率匹配。测定血浆钒浓度并进行组间比较。分析表明，新诊断的2型糖尿病患者的血浆钒浓度显著低于对照组（P = 0.001）。糖尿病患者和非糖尿病患者的平均血浆钒水平分别为1.0 μ g/L和1.2 μ g/L。血浆钒浓度最高四分位数的参与者与最低四分位数的参与者相比，新诊断的2型糖尿病风险显著降低（比值比= 0.26，95%置信区间：0.19，0.35; P < 0.001）。在调整已知的风险因素和进一步的分层分析后，这一趋势仍然显着。我们的研究结果表明，在中国人群中，血浆钒浓度与新诊断的2型糖尿病呈负相关。
Vanadium compounds have been proposed to have beneficial effects on the pathogenesis and complications of type 2 diabetes. Our objective was to evaluate the association between plasma vanadium levels and type 2 diabetes. We performed a case-control study involving 1,598 Chinese subjects with or without newly diagnosed type 2 diabetes (December 2004-December 2007). Cases and controls were frequency-matched by age and sex. Plasma vanadium concentrations were measured and compared between groups. Analyses showed that plasma vanadium concentrations were significantly lower in cases with newly diagnosed type 2 diabetes than in controls (P = 0.001). Mean plasma vanadium levels in participants with and without diabetes were 1.0 mu g/L and 1.2 mu g/L, respectively. Participants in the highest quartile of plasma vanadium concentration had a notably lower risk of newly diagnosed type 2 diabetes (odds ratio = 0.26, 95% confidence interval: 0.19, 0.35; P < 0.001), compared with persons in the lowest quartile. The trend remained significant after adjustment for known risk factors and in further stratification analyses. Our results suggested that plasma vanadium concentrations were inversely associated with newly diagnosed type 2 diabetes in this Chinese population.