INTERLEUKIN-4 (B-CELL STIMULATORY FACTOR-I) CAN ENHANCE OR ANTAGONIZE THE FACTOR-DEPENDENT GROWTH OF HEMATOPOIETIC PROGENITOR CELLS
INTERLEUKIN-4 (B-CELL STIMULATORY FACTOR-I) CAN ENHANCE OR ANTAGONIZE THE FACTOR-DEPENDENT GROWTH OF HEMATOPOIETIC PROGENITOR CELLS
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DOI：
10.1073/pnas.84.19.6889
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发表时间：
1987-10-01
影响因子：
11.1
通讯作者：
GEMMELL, L
中科院分区：
文献类型：
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作者：
RENNICK, D;YANG, G;GEMMELL, L
我们的研究表明，虽然白细胞介素4（IL-4）不能刺激显着的集落形成的骨髓祖细胞，它增强红细胞，粒细胞，巨噬细胞和肥大细胞集落形成时，作为共刺激物与促红细胞生成素，粒细胞集落刺激因子，巨噬细胞集落刺激因子，白细胞介素3（IL-3），分别使用。相反，IL-4抑制粒细胞和巨噬细胞祖细胞以及多能祖细胞的IL-3依赖性集落形成。此外，它似乎抑制从未成熟IL-3依赖性干细胞体外生成集落形成祖细胞。我们还发现IL-4抑制骨髓来源的前B细胞的基质细胞依赖性生长。IL-4直接或间接调节祖细胞生长的积极和消极方面的能力进行了讨论。
Our studies show that although interleukin 4 (IL-4) fails to stimulate significant colony formation by bone marrow progenitor cells, it enhances erythroid, granulocyte, macrophage, and mast-cell colony formation when used as a costimulant with erythropoietin, granulocyte colony-stimulating factor, macrophage colony-stimulating factor, and interleukin 3 (IL-3), respectively. In contrast, IL-4 suppresses IL-3 dependent colony formation by granulocyte and macrophage progenitor cells and by multipotential progenitor cells. Furthermore, it appears to inhibit the in vitro generation of colony-forming progenitor cells from immature IL-3 dependent stem cells. We also found that IL-4 inhibits stromal cell-dependent growth of bone marrow-derived pre-B cells. The ability of IL-4 to directly or indirectly regulate both positive and negative aspects of progenitor cell growth is discussed.