Quantification of patterns of regional cardiac metabolism.
Quantification of patterns of regional cardiac metabolism.
复制标题
区域心脏代谢模式的量化。
DOI：
10.1148/radiology.176.3.2389023
复制
发表时间：
1990
期刊：
影响因子：
19.7
通讯作者：
Ackermann,RF
中科院分区：
文献类型：
--
作者：
Lear,JL;Ackermann,RF
为了定量绘制和比较区域心脏代谢模式，其空间分辨率比正电子发射断层扫描（PET）更高，作者开发了放射自显影技术，用于放射性标记的氟代脱氧葡萄糖（FDG）、葡萄糖（GLU）和醋酸盐（ACE）的组合，并将该技术应用于正常大鼠。开发动力学模型以比较基于Glu的氧化葡萄糖代谢与基于FDG的总葡萄糖代谢（氧化加厌氧），并比较基于ACE的总体氧化代谢与基于FDG的总葡萄糖代谢。基于葡萄糖的代谢通常优于基于葡萄糖的代谢，但在某些结构中发生分歧，如乳头肌，其中基于葡萄糖的代谢要大得多。ACE代谢通常也高于FDG代谢，但同样，乳头肌的FDG代谢相对更高。基于FDG的代谢和基于GLU或ACE的代谢之间的这些差异表明存在高水平的无氧糖酵解。因此，该研究表明，无氧糖酵解，除了发生在缺血或"顿抑"心肌（如最近的PET研究所示），正常发生在特定的心脏区域，尽管存在丰富的氧气。
To quantitatively map and compare patterns of regional cardiac metabolism with greater spatial resolution than is possible with positron emission tomography (PET), the authors developed autoradiographic techniques for use with combinations of radiolabeled fluorodeoxyglucose (FDG), glucose (GLU), and acetate (ACE) and applied the techniques to normal rats. Kinetic models were developed to compare GLU-based oxidative glucose metabolism with FDG-based total glucose metabolism (oxidative plus anaerobic) and to compare ACE-based overall oxidative metabolism with FDG-based total glucose metabolism. GLU-based metabolism generally paralleled FDG-based metabolism, but divergence occurred in certain structures such as the papillary muscles, where FDG-based metabolism was much greater. ACE-based metabolism also generally paralleled FDG-based metabolism, but again, the papillary muscles had relatively greater FDG-based metabolism. These discrepancies between FDG-based metabolism and GLU- or ACE-based metabolism suggest the presence of high levels of anaerobic glycolysis. Thus, the study indicates that anaerobic glycolysis, in addition to occurring in ischemic or "stunned" myocardium (as has been shown in recent PET studies), occurs normally in specific cardiac regions, despite the presence of abundant oxygen.