Gorham-Stout syndrome presenting in a 5-year-old girl with a successful bisphosphonate therapeutic effect.
Gorham-Stout syndrome presenting in a 5-year-old girl with a successful bisphosphonate therapeutic effect.
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一名 5 岁女孩出现 Gorham-Stout 综合征，双膦酸盐取得成功治疗效果
DOI：
10.3892/etm.2012.622
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发表时间：
2012-09
影响因子：
2.7
通讯作者：
Huang ZZ
中科院分区：
文献类型：
--
作者：
Zheng MW;Yang M;Qiu JX;Nan XP;Huang LY;Zhang WD;Gong L;Huang ZZ
Gorham-Stout syndrome (GSS), also known as Gorham-Stout disease, massive osteolysis, disappearing bone disease or phantom bone, is a rare disorder of the musculo-skeletal system. It most commonly involves the skull, shoulder and pelvic girdle. Histological examination reveals a progressive osteolysis always associated with an angiomatosis of blood vessels and sometimes of lymphatics, which seemingly is responsible for the destruction of the bone. It is extremely rare that Gorham-Stout syndrome involves the bones of the entire body. A 5-year-old girl complaining of intermittent and dull back pain for 3 months was admitted to a local hospital. X-ray revealed left pleural effusion, and the patient was diagnosed with tuberculous pleurisy. Thus, anti-tuberculosis therapy was performed. However, it was not effective. A soft mass with significant tenderness was found in the upper segment of the right leg 50 days afterwards. X-ray revealed multiple osteolysis of the bilateral clavicle, scapula, rib, vertebral body, ilium, sacrum, femur and tibia. The biopsy from the right tibia disclosed that the lesion was composed of hyperplastic blood vessels and fibrous tissues similar to hemangioma. Based on the above clinical, radiological and histopathological findings, the clinical physician confirmed a diagnosis of Gorham-Stout disease, and prescribed oral anti-osteoclastic medications consisting of bisphosphonates. At present, the girl is alive and healthy, and new lesions have not been noted.
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影响因子：
1.4
作者：
Patel, Dipak V.
通讯作者：
Patel, Dipak V.
DOI：
10.1016/s1079-2104(00)80027-x
发表时间：
2000-01-01
期刊：
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY
影响因子：
--
作者：
Holroyd, I;Dillon, M;Roberts, GJ
通讯作者：
Roberts, GJ
DOI：
10.1302/0301-620x.81b3.9468
发表时间：
1999-05-01
影响因子：
--
作者：
Möller, G;Priemel, M;Delling, G
通讯作者：
Delling, G
DOI：
10.2106/00004623-195537050-00008
发表时间：
1955-01-01
影响因子：
5.3
作者：
GORHAM, LW;STOUT, AP
通讯作者：
STOUT, AP
影响因子：
168.9
作者：
Hagberg, F;Lamberg, K;Åström, G
通讯作者：
Åström, G