Enhancement of memory-related long-term facilitation by ApAF, a novel transcription factor that acts downstream from both CREB1 and CREB2
Enhancement of memory-related long-term facilitation by ApAF, a novel transcription factor that acts downstream from both CREB1 and CREB2
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DOI：
10.1016/s0092-8674(00)00163-x
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发表时间：
2000-11-10
期刊：
影响因子：
64.5
通讯作者：
Kandel, ER
中科院分区：
文献类型：
--
作者：
Bartsch, D;Ghirardi, M;Kandel, ER
记忆敏感性的鳃回缩反射在Astrasia反映在促进的感觉和运动神经元之间的单突触连接的反射。从短期到长期的转换需要CREB 1的激活，ApCREB 2的去抑制和ApC/EBP的诱导。在寻找CREB 1下游作用的基因时，我们已经确定了一种转录激活因子ApAF，它受蛋白激酶A刺激，可以与ApC/EBP和ApCREB 2二聚化。ApAF对于5次5-羟色胺脉冲、CREB 1激活或ApCREB 2去抑制诱导的长期易化是必需的。ApAF的过表达进一步增强了这种长期易化作用。因此，ApAF是CREB 1和ApCREB 2下游的候选记忆增强基因。
The memory for sensitization of the gill withdrawal reflex in Aplysia is reflected in facilitation of the monosynaptic connection between the sensory and motor neurons of the reflex. The switch from short- to longterm facilitation requires activation of CREB1, derepression of ApCREB2, and induction of ApC/EBP. In search for genes that act downstream from CREB1, we have identified a transcription activator, ApAF, which is stimulated by protein kinase A and can dimerize with both ApC/EBP and ApCREB2. ApAF is necessary for long-term facilitation induced by five pulses of serotonin, by activation of CREB1, or by derepression of ApCREB2. Overexpression of ApAF enhances the long-term facilitation further. Thus, ApAF is a candidate memory enhancer gene downstream from both CREB1 and ApCREB2.