Effects of beta-receptor blockade and angiotensin II type I receptor antagonism in isoproterenol - Induced heart failure in the rat
Effects of beta-receptor blockade and angiotensin II type I receptor antagonism in isoproterenol - Induced heart failure in the rat
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DOI：
10.1016/s1054-8807(99)00021-6
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发表时间：
1999-11-01
影响因子：
3.7
通讯作者：
Kromer, EP
中科院分区：
文献类型：
--
作者：
Grimm, D;Holmer, SR;Kromer, EP
本研究的目的是研究氯沙坦（LOS）和美托洛尔（MP）对血管紧张素II型受体拮抗剂在异丙肾上腺素诱导的大鼠心脏损伤中的作用。应用异丙肾上腺素（ISO） 2周后，对90只ISO大鼠和30只对照大鼠进行检查。ISO大鼠分别用LOS、MP或载药治疗2周（每组n = 30）。与对照组相比，ISO诱导左心室肥厚（LVH）、纤维化和细胞外基质蛋白的过度表达。LOS显著减弱了这些变化。MP仅降低LVH，但对结构改变无影响。左室舒张末期压和平均右心房压在ISO组显著升高，在LOS和MP组恢复正常。与对照组相比，ISO组的平均主动脉血流速度显著降低，而LOS和MP组的平均主动脉血流速度不变。ISO和LOS大鼠血压均降低。MP治疗对血压没有影响，但显著降低了心率。异丙肾上腺素引起轻度心力衰竭。氯沙坦和美托洛尔应用于iso治疗的大鼠对血流动力学改变和LVH的减弱非常有效。异丙肾上腺素引起的心脏损伤后24小时早期应用氯沙坦对心肌结构有显著的有益作用。(C) 1999 Elsevier Science Inc.；
The aim of this study was to examine the effects of both angiotensin II type I receptor antagonism using losartan (LOS) and beta-receptor blockade by metoprolol (MP) in isoproterenol-induced cardiac injury in the rat. Two weeks after isoproterenol (ISO) application, 90 ISO and 30 control (CTRL) rats were examined. ISO rats were treated for two weeks with either LOS, MP, or vehicle (n = 30 each group). Compared to CTRL, ISO induced left ventricular hypertrophy (LVH), fibrosis, and overexpression of extracellular matrix proteins. LOS significantly attenuated these changes. MP only reduced LVH, but exerted no effect on structural alterations. LV end-diastolic and mean right atrial pressures were significantly increased in the ISO group and normalized in the LOS and MP group. Mean aortic blood flow velocity was significantly decreased in the ISO group and unaltered in the LOS and MP group versus CTRL. Blood pressure was decreased in ISO and LOS rats. MP treatment had no effect on blood pressure, but significantly lowered heart rate. Isoproterenol induced mild heart failure. Losartan and metoprolol applications in ISO-treated rats were highly effective in attenuating hemodynamic alterations and LVH. Early application of losartan 24 hours after isoproterenol-induced cardiac injury revealed significant beneficial effects on myocardial structure. (C) 1999 Elsevier Science Inc.