Development of Robust Heterogeneous Chiral Rhodium Catalysts Utilizing Acid?Base and Electrostatic Interactions for Efficient Continuous-Flow Asymmetric Hydrogenations
Development of Robust Heterogeneous Chiral Rhodium Catalysts Utilizing Acid?Base and Electrostatic Interactions for Efficient Continuous-Flow Asymmetric Hydrogenations
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利用酸碱和静电相互作用开发鲁棒的多相手性铑催化剂以实现高效的连续流不对称氢化
DOI：
10.1021/jacs.0c08109
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发表时间：
2020
影响因子：
15
通讯作者：
Kobayashi Shu
中科院分区：
文献类型：
--
作者：
Saito Yuki;Kobayashi Shu
已经开发了基于酸碱和静电相互作用的多相手性Rh催化剂。该稳健的催化剂在各种酰胺和脱氢氨基酸的连续流动不对称氢化中表现出高活性和选择性，提供光学活性酰胺而不浸出金属物质。通过改变手性配体可以很容易地调节手性环境，这表明多相催化剂具有很高的通用性。通过应用这些高效催化剂，实现了几种活性药物成分中间体的连续合成。
Heterogeneous chiral Rh catalysts based on acid–base and electrostatic interactions have been developed. The robust catalysts demonstrate high activity and selectivity in the continuous-flow asymmetric hydrogenation of a wide variety of enamides and dehydroamino acids, providing optically active amides without leaching of metal species. The chiral environments can be easily tuned by changing the chiral ligands, demonstrating the high versatility of the heterogeneous catalysts. By applying these efficient catalysts, continuous synthesis of several active pharmaceutical ingredient intermediates was achieved.