Adipose Tissue-Liver Cross Talk in the Control of Whole-Body Metabolism: Implications in Nonalcoholic Fatty Liver Disease
Adipose Tissue-Liver Cross Talk in the Control of Whole-Body Metabolism: Implications in Nonalcoholic Fatty Liver Disease
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DOI：
10.1053/j.gastro.2019.12.054
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发表时间：
2020-05-01
期刊：
影响因子：
29.4
通讯作者：
Vidal-Puig, Antonio
中科院分区：
文献类型：
--
作者：
Azzu, Vian;Vacca, Michele;Vidal-Puig, Antonio
脂肪组织和肝脏在调节全身能量平衡方面发挥着重要作用，但它们还没有进化到能够科普肥胖症中出现的持续、慢性、营养过剩。在这篇综述中，我们详细介绍了长期代谢应激如何导致脂肪组织功能障碍、炎症和脂肪因子释放，从而导致脂质流向肝脏的增加。总的来说，伴随胰岛素抵抗状态的肝脏脂肪蓄积的结果是肝脏脂质酶途径被调节和压倒，导致有毒脂质物质的选择性积聚，这破坏了在非酒精性脂肪性肝炎中观察到的促炎和促纤维化转变。
Adipose tissue and the liver play significant roles in the regulation of whole-body energy homeostasis, but they have not evolved to cope with the continuous, chronic, nutrient surplus seen in obesity. In this review, we detail how prolonged metabolic stress leads to adipose tissue dysfunction, inflammation, and adipokine release that results in increased lipid flux to the liver. Overall, the upshot of hepatic fat accumulation alongside an insulin-resistant state is that hepatic lipid enzymatic pathways are modulated and overwhelmed, resulting in the selective buildup of toxic lipid species, which worsens the pro-inflammatory and pro-fibrotic shift observed in nonalcoholic steatohepatitis.