Postprandial anti-inflammatory and antioxidant effects of extra virgin olive oil
Postprandial anti-inflammatory and antioxidant effects of extra virgin olive oil
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DOI：
10.1016/j.atherosclerosis.2006.01.011
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发表时间：
2007-01-01
期刊：
影响因子：
5.3
通讯作者：
Visioli, Francesco
中科院分区：
文献类型：
--
作者：
Bogani, Paola;Galli, Claudio;Visioli, Francesco
餐后高血脂浓度与氧化应激增加有关，氧化应激反过来又增加动脉粥样硬化的风险。流行病学研究表明较低的心血管疾病发病率与坚持地中海饮食有关。这项研究的目的是评估12名正常血脂的健康受试者在接受高脂饮食后，除了经典的血脂参数外，炎症(TXB2和LTB4)和氧化应激标志物(尿过氧化氢水平和血清抗氧化能力)的变化。按照拉丁方设计，受试者被分成三组，每组接受一种不同类型的油(特级初榨橄榄油；EVOO橄榄油；00或玉米油；CO，以及150克土豆)，在治疗之间进行两周的洗涤。分别于餐后1小时、2小时、6小时采血。服用EVOO(但不包括00或CO)后2小时和6小时，炎性标志物TXB_2和LTB_4显著降低，同时血清抗氧化能力增加。这些数据强化了地中海饮食减少冠心病发病率的观点，部分原因是其酚类成分，包括特级初榨橄榄油的保护作用。(C)2006爱思唯尔爱尔兰有限公司。保留所有权利。
High postprandial serum lipid concentrations are associated with increased oxidative stress which, in turn, increases the risk of atherosclerosis. Epidemiological studies correlate lower incidence of cardiovascular disease with adherence to the Mediterranean diet.The aim of this study was to evaluate changes in inflammatory (TXB2, and LTB4) and oxidative stress markers (urinary hydrogen peroxide levels and serum antioxidant capacity), in addition to classic lipid parameters, after a fat-rich meal administered to 12 normolipemic, healthy subjects. Following a Latin square design, subjects were divided into three,groups, each one receiving a different kind of oil (extra virgin olive oil; EVOO, olive oil; 00 or corn oil; CO, together with 150g of potatoes), with 2-week washout periods between treatments. Blood samples were drawn at baseline and after 1, 2, and 6h after the meal. A significant decrease in inflammatory markers, namely TXB2, and LTB4, after 2 and 6 h after EVOO (but not 00 or CO) consumption and a concomitant increase of serum antioxidant capacity were recorded. These data reinforce the notion that the Mediterranean diet reduces the incidence of coronary heart disease partially due to the protective role of its phenolic components, including those of extra virgin olive oil. (c) 2006 Elsevier Ireland Ltd. All rights reserved.