Clinical investigation of oral cancer in Adolescent and Young Adult （AYA） generation
Clinical investigation of oral cancer in Adolescent and Young Adult （AYA） generation
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青少年（AYA）一代口腔癌的临床研究
DOI：
10.11277/stomatology.68.20
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
岡本 哲治
中科院分区：
文献类型：
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作者：
吉岡 幸男;坂上 泰士;松井 健作;津島 康司;大林 史誠;濱田 充子;山崎 佐知子;浜名 智昭;角 健作;神田 拓;小泉 浩一;谷 亮治;林堂 安貴;笹原 妃佐子;伊藤 翼;佐渡 友浩;石田 康隆;岡本 康正;小林 雅史;坂本 哲彦;明見 能成;虎谷 茂昭;岡本 哲治
术语“青少年和年轻成人（AYA）一代”通常用于肿瘤学。我们回顾性研究了16 ~ 40岁口腔癌患者的临床特征和治疗方法，重点关注性别、年龄分布、肿瘤部位、病理分类、分期、治疗、治疗结果和社会康复等临床项目。共42例患者，男19例，女23例，占我科口腔癌患者总数的5.7%。他们中的大多数人年龄为35至39岁（中位数为30.9岁）。最常见的肿瘤发生部位是舌，最常见的癌症组织学类型是鳞状细胞癌，分别在29和30例AYA癌症患者中。TNM分期以T2 NO为主，早期为Ⅱ期。根治性手术39例，其中单纯手术14例，单纯放化疗6例，手术加化疗4例，手术加放疗2例。另一方面，9例患者接受了根治性放射治疗，其中5例接受了内照射治疗，4例仅接受了放化疗治疗。AYA口腔癌患者的5年总生存率（79.67%）明显上级老年患者（68.48%）（P= 0.034）。7名患者死于癌症。AYA患者的治疗结局良好。32例口腔癌AYA患者，除2例无法随访和1例在调查日继续接受治疗外，均已回归社会。
The term “Adolescent and Young Adult (AYA) generation” is commonly used in oncology. We retrospectively studied both clinical characteristics and therapy in AYA patients with oral cancer who were between 16 and 40 years old at the initial visit to our department, focusing on clinical items such as gender, age distribution, tumor site, pathological classification, stage, treatment, treatment outcome and social rehabilitation. There were 42 patients (male, 19; female, 23), accounting for 5.7% of the total number of patients with oral cancer in our department. Most of them were 35 to 39 years old (median, 30.9 years). The most frequent site of tumor occurrence was the tongue and the most common histological type of cancer was squamous cell carcinoma, in 29 and 30 AYA patients with cancer, respectively. Most patients had T2NO cancer based on the TNM classification and early stage Ⅱ. Thirty-nine patients underwent radical surgery, including 14 cases of surgery only, 6 of chemo-radiation therapy only, 4 of surgery with chemotherapy, and 2 of surgery with radiation therapy. On the other hand, 9 patients underwent radical radiation therapy, including 5 cases of internal irradiation therapy and 4 of chemo-radiation therapy only. The 5-year overall survival rate in AYA patients with oral cancer (79.67%) was statistically superior to that of older patients (68.48%)(P= 0.034). Seven patients died of cancer. Treatment outcomes of AYA patients were favorable. Thirty-two AYA patients with oral cancer, except for 2 patients who could not be followed and 1 patient who had continued to receive treatment on the investigation date, returned to society.