Abnormal glucose tolerance, white blood cell count, and telomere length in newly diagnosed, antidepressant-naive patients with depression
Abnormal glucose tolerance, white blood cell count, and telomere length in newly diagnosed, antidepressant-naive patients with depression
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DOI：
10.1016/j.bbi.2012.11.009
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发表时间：
2013-02-01
影响因子：
15.1
通讯作者：
Kirkpatrick, Brian
中科院分区：
文献类型：
--
作者：
Garcia-Rizo, Clemente;Fernandez-Egea, Emilio;Kirkpatrick, Brian
慢性情绪障碍与端粒缩短有关，端粒缩短是死亡率增加和衰老的标志，也与细胞免疫受损有关。然而，治疗可能会混淆这些关系。我们研究了葡萄糖耐量、白色血细胞计数和端粒长度与新诊断的抗抑郁药初治患者抑郁症的关系。受试者与抑郁症（n = 15），和匹配的健康对照组（n = 70）进行了两个小时的口服葡萄糖耐量试验和血细胞计数和端粒含量的评价。抑郁组的两小时血糖浓度明显高于对照组，淋巴细胞计数明显低于对照组（两小时血糖的平均值[SD]分别为125.0 mg/dL [67.9] vs 84.6 [25.6]（p < .001）;淋巴细胞计数2.1 x 10（9）/L [0.6] vs 2.5 x 10（9）/L [0.7] p = .028）。与对照组受试者（101.0 [14.3]; p < 0.01）相比，抑郁组受试者的端粒含量（87.9 [7.6]）显著缩短。糖耐量异常、淋巴细胞减少和端粒缩短在抑郁症病程早期就存在，与抗抑郁治疗的混杂效应无关，支持重性抑郁症是一种加速衰老疾病的概念。(C)2012 Elsevier Inc. All rights reserved.
Chronic mood disorders have been associated with a shortened telomere, a marker of increased mortality rate and aging, and impaired cellular immunity. However, treatment may confound these relationships. We examined the relationship of glucose tolerance, white blood cell count and telomere length to depression in newly diagnosed, antidepressant-naive patients. Subjects with major depression (n = 15), and matched healthy control subjects (n = 70) underwent a two-hour oral glucose tolerance test and evaluation of blood cell count and telomere content. The depression group had significantly higher two-hour glucose concentrations and a lower lymphocyte count than control subjects (respective means [SD] for two-hour glucose were 125.0 mg/dL [67.9] vs 84.6 [25.6] (p < .001); for lymphocyte count 2.1 x 10(9)/L [0.6] vs 2.5 x 10(9)/L [0.7] p = .028). Telomere content was significantly shortened in the depression group (87.9 [7.6]) compared to control subjects (101.0 [14.3]; p < 0.01). Abnormal glucose tolerance, lymphopenia and a shortened telomere are present early in the course of depression independently of the confounding effect of antidepressant treatment, supporting the concept of major depression as an accelerated aging disease. (C) 2012 Elsevier Inc. All rights reserved.