Functional connectivity in patients with idiopathic generalized epilepsy
Functional connectivity in patients with idiopathic generalized epilepsy
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DOI：
10.1111/j.1528-1167.2010.02938.x
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发表时间：
2011-03-01
期刊：
影响因子：
5.6
通讯作者：
Gotman, Jean
中科院分区：
文献类型：
--
作者：
Moeller, Friederike;Maneshi, Mona;Gotman, Jean
目的：特发性全身性癫痫（Idiopathic generalized epilepsy，IGE）是一种以正常背景活动引起的全身性棘波放电（generalized spike wave discharge，GSWDs）为特征的疾病。虽然GSWD是丘脑皮质网络中高度同步活动的结果，但认为没有GSWD的EEG代表正常的脑活动。本研究的目的是调查是否丘脑皮质的相互作用，甚至在GSWD的EEG期间与IGE.Methods：GSWD相关的组分析进行了12 IGE患者在GSWD期间涉及的领域中定义的种子。然后选择22名IGE患者和30名年龄匹配的健康对照者的EEG功能磁共振成像（fMRI）数据集，以研究GSWD相关区域的功能连接。从GSWD相关组分析定义的种子中提取血氧水平依赖性（BOLD）信号变化。每个种子内的平均时间过程用于检测具有与种子相关的BOLD信号的脑区域。患者和对照组之间的差异进行了estimated.Key结果：GSWD相关的组分析显示，BOLD激活丘脑，前内侧皮层，小脑和BOLD失活的默认模式区。为了进行连接性分析，将8个种子双侧放置在丘脑、内侧额叶皮质、楔前叶和小脑中。这些种子的功能连接分析没有显示出明显改变的功能连接的患者与controls.Significance：结果强调GSWDs的阵发性：虽然GSWDs的特点是高度同步的活动在丘脑皮质网络，在GSWDs涉及的领域的功能连接并没有表现出异常的GSWD自由期间。
P>Purpose:Idiopathic generalized epilepsy (IGE) is characterized by electroencephalography (EEG) recordings with generalized spike wave discharges (GSWDs) arising from normal background activity. Although GSWDs are the result of highly synchronized activity in the thalamocortical network, EEG without GSWDs is believed to represent normal brain activity. The aim of this study was to investigate whether thalamocortical interactions are altered even during GSWD-free EEG periods in patients with IGE.Methods:A GSWD-related group analysis was performed in 12 IGE patients to define seeds in areas involved during GSWDs. EEG-functional magnetic resonance imaging (fMRI) datasets from 22 IGE patients without GSWDs during the investigation and 30 age-matched healthy controls were then selected to investigate functional connectivity in GSWD-related areas. Blood oxygen level dependent (BOLD) signal changes were extracted from seeds defined by the GSWD-related group analysis. The averaged time course within each seed was used to detect brain regions with BOLD signal correlated with the seed. Group differences between patients and controls were estimated.Key Findings:The GSWD-related group analysis showed BOLD activation in the thalamus, the frontomesial cortex, and the cerebellum and BOLD deactivation in default mode areas. For the connectivity analysis, eight seeds were placed bilaterally in the thalamus, mesial frontal cortex, precuneus, and cerebellum. The functional connectivity analysis of these seeds did not show clearly altered functional connectivity for patients versus controls.Significance:The results underscore the paroxysmal nature of GSWDs: Although GSWDs are characterized by highly synchronized activity in the thalamocortical network, the functional connectivity in areas involved during GSWDs does not demonstrate abnormality in GSWD-free periods.