In vitro evaluation of radiopacity of contrast-loaded superabsorbent polymer microspheres (SAP-MS) with static imaging and flow model
In vitro evaluation of radiopacity of contrast-loaded superabsorbent polymer microspheres (SAP-MS) with static imaging and flow model
复制标题
使用静态成像和流动模型体外评估负载造影剂的高吸收性聚合物微球 (SAP-MS) 的射线不透性
DOI：
10.1007/s11604-019-00863-x
复制
发表时间：
2019
影响因子：
2.1
通讯作者：
Kojiro Suzuki
中科院分区：
文献类型：
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作者：
A. Narita;Takahiro Yamamoto;Shuji Ikeda;Yuichiro Izumi;Akira Kitagawa;Mansaku Takeda;K. Murotani;Makiyo Hagihara;T. Ota;T. Ishiguchi;Kojiro Suzuki
目的评价造影剂超吸收聚合物微球（SAP-MS）在X射线成像下的不透性。依次测量在盐水中的造影剂加载的SAP-MS的直径。通过对比度噪声比和多位读片员评分评估对比剂加载SAP-MS的X线摄影的不透射线性和可见性。在数字减影血管造影下，将对比剂加载的SAP-MS注射到流动模型中。流速为1-10 cm/s，使用10-85 ms的脉冲宽度以1-7.5帧/秒采集图像。结果SAP-MS的直径增加到原来的大小的4.0-5.0倍，约15分钟。在盐水中的造影剂加载的SAP-MS的直径在几分钟内进一步增加10-30%，并恢复到先前的尺寸。与生理盐水混合后30 min内，造影剂加载的SAP-MS的不透射线性和可见性降低。结论为获得更好的观察效果，SAP-MS应保存在未稀释的对比剂中，直至使用。建议采用流速较慢和脉冲宽度较窄的条件。
PurposeTo evaluate the radiopacity of contrast-loaded superabsorbent polymer microspheres (SAP-MS) under X-ray imaging.Materials and methodsSAP-MS were suspended in contrast material (iodixanol) and the diameter change was assessed. The diameter of contrast-loaded SAP-MS in saline was measured sequentially. Radiography of the contrast-loaded SAP-MS was evaluated as radiopacity by contrast-to-noise ratio and visibility by multiple reader scoring. Under digital subtraction angiography, contrast-loaded SAP-MS were injected into a flow model. The flow speed was 1–10 cm/s, and images were acquired at 1–7.5 frames per second using a pulse width of 10–85 ms. Images were assessed by multiple reader scoring.ResultsThe diameter of SAP-MS increased to 4.0–5.0 times its original size for approximately 15 min. The diameter of contrast-loaded SAP-MS in saline further increased by 10–30% within several minutes and returned to the previous size. Radiopacity and visibility of contrast-loaded SAP-MS decreased in 30 min after mixing with saline. Visibility was better with slow flow speed and narrow pulse width.ConclusionFor effective observation, contrast-loaded SAP-MS should be kept in non-diluted contrast material until use. The conditions of slower flow and use of a narrow pulse width are recommended.