Palladium-Catalyzed Decarboxylation of Benzyl Fluorobenzoates
Palladium-Catalyzed Decarboxylation of Benzyl Fluorobenzoates
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DOI：
10.1055/s-0036-1588572
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发表时间：
2017-09
期刊：
影响因子：
2
通讯作者：
Y. Makida;Yasutaka Matsumoto;R. Kuwano
中科院分区：
文献类型：
--
作者：
Y. Makida;Yasutaka Matsumoto;R. Kuwano
摘要 采用 Pd(η3-烯丙基)Cp 和大单膦配体 XPhos 原位制备的钯催化剂开发了氟苯甲酸苄酯的脱羧反应。该催化反应以良好的产率提供了一系列氟化二芳基甲烷，并具有广泛的官能团相容性。通过相应的苯甲酸与苯甲醇的缩合很容易合成底物。因此，该转化在形式上被认为是含氟苯甲酸与苯甲醇之间的交叉偶联反应。
Abstract The decarboxylation of benzyl fluorobenzoates has been developed by using the palladium catalyst prepared in situ from Pd(η3-allyl)Cp and bulky monophosphine ligand XPhos. The catalytic reaction afforded a range of fluorinated diarylmethanes in good yields with broad functional-group compatibility. The substrates were readily synthesized by condensation of the corresponding benzoic acid with benzyl alcohol. Therefore, the transformation is formally regarded as a cross-coupling reaction between fluorine-containing benzoic acids and benzyl alcohols.