Widespread somatosensory sensitivity in naturally occurring canine model of osteoarthritis.
Widespread somatosensory sensitivity in naturally occurring canine model of osteoarthritis.
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DOI：
10.1097/j.pain.0000000000000521
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发表时间：
2016-06
期刊：
影响因子：
7.4
通讯作者：
Lascelles BDX
中科院分区：
文献类型：
--
作者：
Knazovicky D;Helgeson ES;Case B;Gruen ME;Maixner W;Lascelles BDX
补充数字内容可在正文中找到。多模式定量感觉阈值测试证明，犬自发性骨关节炎模型具有中枢敏感化现象。骨关节炎(OA)相关的疼痛是导致残疾的主要原因。作为骨性关节炎的结果，中枢敏感化(CS)被认为是人类患者慢性疼痛的一个重要方面，并已通过定量感觉测试(QST)在人群中进行了测量。犬自发性骨性关节炎模型已被认为是一种较好的翻译模型，但CS在该模型中尚未被探索。在这项研究中，对患有和不伴有自发性髋关节或窒息的骨性关节炎的狗进行了QST，以确定在该模型中骨性关节炎是否与CS相关。比较31只慢性骨性关节炎相关疼痛犬(n=31)和23只正常狗(n=23)的机械(von Frey和钝化压力)和热(热和冷)感觉阈值。对狗进行表型和关节疼痛评分，并在患骨性关节炎的关节、颅骨胫骨肌肉和跖背区域进行测试。使用混合效应模型对QST汇总数据进行评估，以了解骨关节炎状态和协变量的影响，并将患有骨关节炎的狗和对照狗进行比较。骨关节炎的存在与所有QST模式中的食指关节、颅骨胫骨肌和跖骨部位的痛觉过敏密切相关。机械性QST评分与关节疼痛总评分呈中度负相关。犬自发性骨性关节炎模型与躯体感觉敏感性有关，可能是CS的征兆。这些数据进一步验证了犬自发性骨性关节炎模型是人类骨性关节炎疼痛状况的合适模型。
Supplemental Digital Content is Available in the Text. The spontaneous osteoarthritis model in dogs shows evidence of central sensitization as evidenced by multimodality quantitative sensory threshold testing. Osteoarthritis (OA)-associated pain is a leading cause of disability. Central sensitization (CS), as a result of OA, is recognized as an important facet of human patients' chronic pain and has been measured in people using quantitative sensory testing (QST) testing. The spontaneous canine OA model has been suggested as a good translational model, but CS has not been explored in this model. In this study, QST was performed on dogs with and without spontaneous hip or stifle OA to determine whether OA is associated with CS in this model. Mechanical (von Frey and blunt pressure) and thermal (hot and cold) sensory thresholds obtained in dogs with chronic OA-associated pain (n = 31) were compared with those of normal dogs (n = 23). Dogs were phenotyped and joint-pain scored, and testing was performed at the OA-affected joint, cranial tibial muscle, and dorsal metatarsal region. QST summary data were evaluated using mixed-effect models to understand the influence of OA status and covariates, and dogs with OA and control dogs were compared. The presence of OA was strongly associated with hyperalgesia across all QST modalities at the index joint, cranial tibial muscle, and metatarsal site. Mechanical QST scores were significantly moderately negatively correlated with total joint-pain scores. The spontaneous canine OA model is associated with somatosensory sensitivity, likely indicative of CS. These data further validate the canine spontaneous OA model as an appropriate model of the human OA pain condition.
影响因子：
15.8
作者：
Burris S;Koester S
通讯作者：
Koester S