Pathway paradigms revealed from the genetics of inflammatory bowel disease.
Pathway paradigms revealed from the genetics of inflammatory bowel disease.
复制标题
DOI：
10.1038/s41586-020-2025-2
复制
发表时间：
2020-02
期刊：
影响因子：
64.8
通讯作者：
Xavier RJ
中科院分区：
文献类型：
--
作者：
Graham DB;Xavier RJ
Inflammatory bowel disease (IBD) is a complex genetic disease that is instigated and amplified by the confluence of multiple genetic and environmental variables that perturb the immune- microbiome axis. The challenge of dissecting pathological mechanisms underlying IBD has spawned the development of transformative approaches in human genetics and functional genomics. Here, we describe IBD as a model disease in the context of leveraging human genetics to dissect cellular and molecular pathway interactions that control homeostasis of the mucosal immune system. Finally, we synthesize emerging insights from multiple experimental approaches into pathway paradigms and discuss future prospects for disease subtype classification and therapeutic intervention.
登录
查看更多内容
影响因子：
32.4
作者：
Campbell EL;Bruyninckx WJ;Kelly CJ;Glover LE;McNamee EN;Bowers BE;Bayless AJ;Scully M;Saeedi BJ;Golden-Mason L;Ehrentraut SF;Curtis VF;Burgess A;Garvey JF;Sorensen A;Nemenoff R;Jedlicka P;Taylor CT;Kominsky DJ;Colgan SP
通讯作者：
Colgan SP
影响因子：
4.8
作者：
Chirieleison, Steven M.;Marsh, Rebecca A.;Abbott, Derek W.
通讯作者：
Abbott, Derek W.
影响因子：
30.8
作者：
Ellinghaus D;Jostins L;Spain SL;Cortes A;Bethune J;Han B;Park YR;Raychaudhuri S;Pouget JG;Hübenthal M;Folseraas T;Wang Y;Esko T;Metspalu A;Westra HJ;Franke L;Pers TH;Weersma RK;Collij V;D'Amato M;Halfvarson J;Jensen AB;Lieb W;Degenhardt F;Forstner AJ;Hofmann A;International IBD Genetics Consortium (IIBDGC);International Genetics of Ankylosing Spondylitis Consortium (IGAS);International PSC Study Group (IPSCSG);Genetic Analysis of Psoriasis Consortium (GAPC);Psoriasis Association Genetics Extension (PAGE);Schreiber S;Mrowietz U;Juran BD;Lazaridis KN;Brunak S;Dale AM;Trembath RC;Weidinger S;Weichenthal M;Ellinghaus E;Elder JT;Barker JN;Andreassen OA;McGovern DP;Karlsen TH;Barrett JC;Parkes M;Brown MA;Franke A
通讯作者：
Franke A
影响因子：
30.8
作者：
Calderon, Diego;Nguyen, Michelle L. T.;Pritchard, Jonathan K.
通讯作者：
Pritchard, Jonathan K.
影响因子：
64.8
作者：
通讯作者：
--