A NEW CANDIDATE FOR THE REGULATION OF ERYTHROPOIESIS - INSULIN-LIKE GROWTH FACTOR-I
A NEW CANDIDATE FOR THE REGULATION OF ERYTHROPOIESIS - INSULIN-LIKE GROWTH FACTOR-I
复制标题
DOI：
10.1016/0014-5793(82)81081-8
复制
发表时间：
1982-01-01
期刊：
影响因子：
3.5
通讯作者：
BAUER, C
中科院分区：
文献类型：
--
作者：
KURTZ, A;JELKMANN, W;BAUER, C
在无血清培养系统中研究了纯人胰岛素样生长因子I（IGF I）对来自胎鼠肝脏和成体骨髓的晚期红系前体细胞（CFU‐e）的殖民地形成的影响。我们发现，IGF I在生理浓度刺激红系集落形成。IGF I和促红细胞生成素的联合作用小于其单独作用之和。IGF I诱导的集落数与接种细胞数呈线性关系。我们的研究结果表明，IGF I是第一个早期定义的有丝分裂原，刺激红细胞分化的晚期阶段独立的促红细胞生成素。
The effect of pure human insulin‐like growth factor I (IGF I) on the colony formation of late stage erythroid precursor cells (CFU‐e) from fetal mouse liver and adult bone marrow was studied in a serum‐free culture system. We found that IGF I in physiological concentrations stimulated erythroid colony formation. The combined effect of IGF I and erythropoietin was smaller than the sum of their single effects. The number of colonies induced by IGF I was linearly dependent on the number of plated cells. Our results indicate that IGF I is the first early defined mitogen that stimulates the late stages of erythroid differentiation independently of erythropoietin.