Enantioseparation of polar pesticides on chiral capillary columns based on permethyl-β-cyclodextrin in matrices of different polarities
Enantioseparation of polar pesticides on chiral capillary columns based on permethyl-β-cyclodextrin in matrices of different polarities
复制标题
DOI：
10.1016/j.microc.2018.03.037
复制
发表时间：
2018-07-01
影响因子：
4.8
通讯作者：
Castells, Cecilia B.
中科院分区：
文献类型：
--
作者：
Menestrina, Fiorella;Ronco, Nicolas R.;Castells, Cecilia B.
本工作描述了用于溶解全甲基-β-环糊精（PM-β-CD）的不同非手性聚合物对极性农药（甲炔禾草灵、敌敌畏、非禾草灵和氢丙酸酯、恶唑禾草灵、甲霜灵和氟吡禾灵酯）外消旋混合物的气相色谱对映体拆分的影响。一个主要目的是引入一个单一的柱，用于几种不同极性农药的稳健和灵敏的对映体分离，这些农药必须在相对较高的温度下进行色谱分析（对映体歧视的不利条件）。特别地，评价了涂有溶解在（14%-氰丙基苯基）（1%-乙烯基）-86%-甲基聚硅氧烷（OV-1701-vi）、（5%-苯基）（1%-乙烯基）-95%-甲基聚硅氧烷（SE-54）或聚乙二醇（Carbowax 20 M）中的PM-β-CD的毛细管柱拆分上述农药的外消旋物的能力。采用类似的商业柱Hydrodex beta-PM作为参考。此外，还研究了非手性聚合物对选择剂与农药的手性相互作用的影响。与PM-β-CD混合在更极性的聚合物中获得的那些相比，对于大多数手性农药，基于极性较小的聚硅氧烷SE-54的相实现的对映体分离更高。结果进一步表明，基于PM-β-CD/SE-54的单柱在分离多种极性农药及其衍生物方面显示出巨大的应用潜力。(C)2018爱思唯尔B. V.保留所有权利。
This work describes the influence of different achiral polymers used to dissolve permethyl-beta-cydodextrin (PM-beta-CD) on the gas chromatographic enantioresolution of racemic mixtures of polar pesticides (mecoprop, dichlorprop, fenoprop and hydroprop esters, fenoxaprop ethyl, metalaxyl, and haloxyfop esters). One main objective was to introduce a single column for robust and sensitive enantioseparations of several and different polar pesticides, which have to be chromatographed at relatively high temperature (unfavorable condition for enantiodiscrimination). In particular, the ability of capillary columns coated with PM-beta-CD dissolved in either (14%-cyanopropylphenyl)(1%-vinyl)-86%-methylpolysiloxane (OV-1701-vi), (5%-phenyl)(1%-vinyl)-95%-methylpolysiloxane (SE-54) or in polyethyleneglycol (Carbowax 20 M), to resolve the racemates of the aforementioned pesticides was evaluated. An analogous commercial column, Hydrodex beta-PM, was taken as reference. In addition, the influence of the achiral polymer in the availability of selector for enantioselective interactions with those pesticides was studied. Enantioseparations achieved with the phase based on the less polar polysiloxane SE-54 were higher for most chiral pesticides as compared with those obtained with PM-beta-CD mixed in more polar polymers. The results furthermore indicate that a single column based on PM-beta-CD/SE-54 exhibited great potential for application in the separation of a wide variety of polar pesticides and their derivatives. (C) 2018 Elsevier B.V. All rights reserved.