Dihydrostilbene glycosides from Camellia sasanqua and their α-glucosidase and α-amylase inhibitory activities.
Dihydrostilbene glycosides from Camellia sasanqua and their α-glucosidase and α-amylase inhibitory activities.
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茶梅中的二氢二苯乙烯苷及其α-葡萄糖苷酶和α-淀粉酶抑制活性。
DOI：
10.1080/14786419.2020.1756802
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发表时间：
2021
影响因子：
2.2
通讯作者：
Nhiem,NguyenXuan
中科院分区：
文献类型：
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作者：
Cuc,NguyenThi;Cuong,NguyenThe;Anh,LuuThe;Yen,DuongThiHai;Tai,BuiHuu;ThuTrang,Duong;Yen,PhamHai;Kiem,PhanVan;Nam,NguyenHoai;Minh,ChauVan;Nhiem,NguyenXuan
用层析方法从油茶中分离得到3个新的二氢二苯乙烯苷类化合物，即二氢二苯乙烯苷A-C(1-3)和4个已知化合物：儿茶素(4)、芦丁(5)、烟苷(6)和地黄苷A(7)。通过波谱方法(1 D-核磁共振，2 D-核磁共振)和质谱学方法确定了它们的化学结构。化合物1-7对α-葡萄糖苷酶和α-淀粉酶的抑制作用进行了评价。化合物3和4具有α-葡萄糖苷酶抑制活性，其IC50值分别为77.6 ± 1.6和72.4 ± 1.3 μM。化合物1具有抑制α-淀粉酶活性，其IC50值为53.7 ± 1.6 μM。
Using chromatographic methods, three new dihydrostilbene glycosides, sasastilbosides A-C (1-3) and four known compounds, catechin (4), rutin (5), nicotiflorin (6), and rehmaionoside A (7) have been isolated fromCamellia sasanquaThunb. Their chemical structures were elucidated by spectroscopic methods (1 D-, 2 D-NMR) and mass spectra. Compounds1-7were evaluated forα-glucosidase andα-amylase inhibitory effects. Compounds3and4showedα-glucosidase inhibitory activity with IC50values of 77.6 ± 1.6 and 72.4 ± 1.3 μM, respectively. Compound1showedα-amylase inhibitory activity with IC50value of 53.7 ± 1.6 μM.