Comparison of corneal endothelial cell density and morphology after posterior chamber phakic intraocular lens implantation with and without a central hole
Comparison of corneal endothelial cell density and morphology after posterior chamber phakic intraocular lens implantation with and without a central hole
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DOI：
10.1136/bjophthalmol-2016-309363
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发表时间：
2017-11-01
影响因子：
4.1
通讯作者：
Igarashi, Akihito
中科院分区：
文献类型：
--
作者：
Goukon, Hiroyasu;Kamiya, Kazutaka;Igarashi, Akihito
目的比较有晶状体眼后房型人工透镜（hole implanted collamer透镜，ICL）和无中心孔人工晶状体（conventional ICL）植入术后角膜内皮细胞的变化。术前、术后3个月、术后1年和2年，我们使用非接触式角膜内皮显微镜（EM-3000，Tomey）比较两组之间的中央角膜内皮细胞密度（ECD）、细胞大小变异系数（CV）和六边形细胞百分比（HEX）。结果孔型ICL和传统型ICL植入后2年，中心ECD平均丢失率分别为0.3%和1.1%（Mann-Whitney U检验，p=0.72）。结论两种ICL植入术后2年角膜内皮细胞密度、形态、多态性均无明显变化，但ICL植入术后角膜内皮细胞密度、形态、多态性均无明显变化，ICL植入术后角膜内皮细胞密度、形态、多态性均无明显变化，ICL植入术后角膜内皮细胞密度、形态、多态性均无明显变化，但ICL植入术后角膜内皮细胞密度、形态、多态性均无明显变化，ICL植入术后角膜内皮细胞密度、形态、多态性均无明显变化。除了常规ICL注入后的上级区域中的密度。然而，孔ICL植入可能仅在上级区域的密度方面优于传统ICL植入，这可能是因为术前激光虹膜切开术是不必要的。
Aim To compare the corneal endothelial cells after posterior chamber phakic intraocular lens with and without a central hole (hole implantable collamer lens (ICL) and conventional ICL) implantation for the correction of moderate to high myopia.Methods This retrospective study evaluated 34 eyes of 34 patients who underwent hole ICL implantation and 25 eyes of 25 patients who underwent conventional ICL implantation. Preoperatively and 3 months, and 1 and 2 years postoperatively, we compared the central corneal endothelial cell density (ECD), coefficient of variation in cell size (CV) and the percentage of hexagonal cells (HEX) between the two groups using a non-contact specular microscope (EM-3000, Tomey). Preoperatively and 2 years postoperatively, we also compared them in the peripheral regions.Results The mean central ECD loss was 0.3% and 1.1%, 2 years after hole ICL and conventional ICL implantation, respectively (Mann-Whitney U test, p=0.72). There were no significant changes in central ECD, CV or HEX at any time points either after hole ICL or conventional ICL implantation, and a significant decrease only in terms of ECD in the superior regions after conventional ICL implantation.Conclusions Both ICLs do not induce a significant change in the density, polymegethism or polymorphism of corneal endothelial cells even 2 years postoperatively, except for the density in the superior regions after conventional ICL implantation. However, hole ICL implantation may have advantages over conventional ICL implantation only in terms of the density in the superior regions, possibly because preoperative laser iridotomies are unnecessary.