Decrypting a path based approach for identifying the interplay between PI3K and GSK3 signaling cascade from the perspective of cancer.
Decrypting a path based approach for identifying the interplay between PI3K and GSK3 signaling cascade from the perspective of cancer.
复制标题
从癌症的角度解密用于鉴定PI3K和GSK 3信号级联之间相互作用的基于路径的方法。
DOI：
10.1016/j.gendis.2021.12.025
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发表时间：
2022-07
期刊：
影响因子：
6.8
通讯作者：
Roy, Souvik
中科院分区：
文献类型：
--
作者：
Das, Abhijit;Bhattacharya, Barshana;Roy, Souvik
癌症是世界范围内的主要疾病之一，每年夺去数百万人的生命。研究人员一直在寻找根除这种致命疾病的具体方法，以确保沿着更大的治疗意义，将不良反应降到最低。针对不同的异常调节的信号通路，参与癌症，无疑是一个革命性的化疗方法。在这种情况下，GSK3和PI3K信号级联被认为是致癌激活和失活的重要角色，这进一步导致癌症增殖和转移。本文综述了GSK 3和PI3K信号通路在肿瘤中的作用，并通过阐述它们在肿瘤中的交叉激活、交叉抑制和会聚通路，进一步阐明了PI3K和GSK 3信号通路之间的相互作用。我们还展示了GSK3对PI3K抑制剂的功效的影响，以克服耐药性并以与GSK3抑制剂组合的方式防止细胞增殖、转移，以在临床环境中获得更好的治疗策略。
Cancer is one of those leading diseases worldwide, which takes millions of lives every year. Researchers are continuously looking for specific approaches to eradicate the deadly disease, ensuring minimal adverse effects along with more therapeutic significance. Targeting of different aberrantly regulated signaling pathways, involved in cancer, is surely one of the revolutionary chemotherapeutic approach. In this instance, GSK3 and PI3K signaling cascades are considered as important role player for both the oncogenic activation and inactivation which further leads to cancer proliferation and metastasis. In this review, we have discussed the potential role of GSK3 and PI3K signaling in cancer, and we further established the crosstalk between PI3K and GSK3 signaling, through showcasing their cross activation, cross inhibition and convergence pathways in association with cancer. We also exhibited the effect of GSK3 on the efficacy of PI3K inhibitors to overcome the drug resistance and preventing the cell proliferation, metastasis in a combinatorial way with GSK3 inhibitors for a better treatment strategy in clinical settings.
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