Distinct neuropsychological profiles of three major symptom dimensions in obsessive-compulsive disorder
Distinct neuropsychological profiles of three major symptom dimensions in obsessive-compulsive disorder
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DOI：
10.1016/j.psychres.2010.08.001
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发表时间：
2011-05-15
影响因子：
11.3
通讯作者：
Furukawa, Toshi A.
中科院分区：
文献类型：
--
作者：
Hashimoto, Nobuhiko;Nakaaki, Shutaro;Furukawa, Toshi A.
最近的神经影像学研究表明，不同的症状维度是由部分不同的神经系统介导的强迫症（OCD）。然而，强迫症的神经心理特征和症状维度之间的相关性尚不清楚。本研究的目的是探讨强迫症症状维度与情景记忆、注意力和执行功能的相关程度。采用Padua量表和Y-BOCS症状自评量表对63例强迫症患者的症状维度进行评估。然后，我们管理韦氏记忆量表修订版（WMR-R）测试的逻辑记忆（LM）子集，并评估抑制（Stroop测试）。连线测试）和认知灵活性（数字符号测试，字母流畅性和类别流畅性）。虽然在污染/清洁维度上的分数与LM和Trail Making测试的更好表现之间观察到了关联，但在攻击/检查维度上的分数与Trail Making测试的较差表现之间也观察到了关联。此外，我们发现，分数的对称性/有序维度与较差的性能LM和Trail Making测试。我们的研究结果支持这一假设，不同的症状可能代表不同的和部分重叠的神经认知网络强迫症患者。(C)2010爱思唯尔爱尔兰有限公司版权所有。
Recent neuroimaging studies have suggested that different symptom dimensions are mediated by partially distinct neural systems in obsessive-compulsive disorder (OCD). However, the correlations between neuropsychological profiles and symptom dimensions in OCD are unknown. The aim of this study was to examine the extent to which OCD symptom dimensions were associated with episodic memory and attention and executive functions. The symptom dimensions of 63 patients with OCD were assessed using both the Padua Inventory and the Y-BOCS symptom checklist. Then, we administered the Logical Memory (LM) subset of the Wechsler Memory Scale-Revised (WMR-R) test and evaluated inhibition (Stroop test. Trail Making test) and cognitive flexibility (Digit Symbol test, Letter Fluency, and Category Fluency). While associations were observed between scores on the contamination/cleaning dimension and better performances on the LM and Trail Making tests, associations were also observed between scores on the aggressive/checking dimension and poorer performances on the Trail Making test. In addition, we found that scores on the symmetry/ordering dimension were associated with poorer performances on the LM and Trail Making tests. Our results support the hypothesis that different symptoms may represent distinct and partially overlapping neurocognitive networks in OCD patients. (C) 2010 Elsevier Ireland Ltd. All rights reserved.