Left-right patterning: conserved and divergent mechanisms
Left-right patterning: conserved and divergent mechanisms
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DOI：
10.1242/dev.061606
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发表时间：
2012-09-15
期刊：
影响因子：
4.6
通讯作者：
Hamada, Hiroshi
中科院分区：
文献类型：
--
作者：
Nakamura, Tetsuya;Hamada, Hiroshi
内脏器官的左右（LR）不对称性是它们在体内的功能和位置的基础。在过去的十年左右，这种LR不对称性建立的分子机制已被揭示在许多脊椎动物和无脊椎动物的模式生物。这些研究已经确定了一个有助于这一过程的基因网络，并且从海胆到小鼠都高度保守。相比之下，这个过程中的一些特定步骤，如破坏器官的事件和特定部位的器官发生，似乎在进化过程中出现了分歧。在这里，我们总结了常见的和不同的机制，LR不对称性是建立在脊椎动物。
The left-right (LR) asymmetry of visceral organs is fundamental to their function and position within the body. Over the past decade or so, the molecular mechanisms underlying the establishment of such LR asymmetry have been revealed in many vertebrate and invertebrate model organisms. These studies have identified a gene network that contributes to this process and is highly conserved from sea urchin to mouse. By contrast, some specific steps of the process, such as the symmetry-breaking event and situs-specific organogenesis, appear to have diverged during evolution. Here, we summarize the common and divergent mechanisms by which LR asymmetry is established in vertebrates.