Noisy neighbourhoods: quorum sensing in fungal-polymicrobial infections.
Noisy neighbourhoods: quorum sensing in fungal-polymicrobial infections.
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DOI：
10.1111/cmi.12490
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发表时间：
2015-10
影响因子：
3.4
通讯作者：
Hall RA
中科院分区：
文献类型：
--
作者：
Dixon EF;Hall RA
群体感应曾经被认为是一种物种能够感知其细胞密度并相应地调节基因表达的方式。然而，现在越来越明显的是，多种微生物可以感知特定的群体感应分子，使它们能够感知和响应附近的其他微生物。这种相互作用在多微生物疾病的背景下是重要的，其中微生物的竞争或合作可以改变疾病的进展。真菌是人体微生物组中一个小但重要的组成部分，并与细菌和病毒不断接触。真菌群体感应途径的发现导致了许多界间群体感应相互作用的特征。在这里，我们回顾了最近的事态发展，在医学上重要的真菌群体感应，这些相互作用对宿主的先天免疫反应的影响。
Quorum sensing was once considered a way in which a species was able to sense its cell density and regulate gene expression accordingly. However, it is now becoming apparent that multiple microbes can sense particular quorum‐sensing molecules, enabling them to sense and respond to other microbes in their neighbourhood. Such interactions are significant within the context of polymicrobial disease, in which the competition or cooperation of microbes can alter disease progression. Fungi comprise a small but important component of the human microbiome and are in constant contact with bacteria and viruses. The discovery of quorum‐sensing pathways in fungi has led to the characterization of a number of interkingdom quorum‐sensing interactions. Here, we review the recent developments in quorum sensing in medically important fungi, and the implications these interactions have on the host's innate immune response.