Vaccines to Emerging Viruses: Nipah and Hendra.
Vaccines to Emerging Viruses: Nipah and Hendra.
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新兴病毒的疫苗：Nipah和Hendra。
DOI：
10.1146/annurev-virology-021920-113833
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发表时间：
2020-09-29
影响因子：
11.3
通讯作者：
Broder CC
中科院分区：
文献类型：
--
作者：
Amaya M;Broder CC
亨德拉病毒(HEV)和尼帕病毒(NIV)是20世纪90年代中后期在澳大利亚和马来西亚分别在牲畜和人的严重疾病暴发中发现的蝙蝠传播的人畜共患副粘病毒。HEV病毒在澳大利亚反复出现，而新城疫病毒继续在南亚(孟加拉国和印度)造成疫情，这些病毒仍然是跨界威胁。在人类和几种哺乳动物中，HEV和NIV感染是一种严重的全身性疾病，通常是致命的神经和/或呼吸道疾病。尼罗河病毒因其相关的高病死率和人际传播能力而脱颖而出，成为一种潜在的大流行威胁。针对HEV和NIV的有效疫苗的开发一直是研究的重点。在这里，我们回顾了新城疫和戊型肝炎疫苗开发的进展，重点是那些已经在已建立的新城疫和戊型肝炎病毒感染和疾病的动物挑战模型中测试的方法。
Hendra virus (HeV) and Nipah virus (NiV) are bat-borne zoonotic paramyxoviruses identified in the mid- to late 1990s in outbreaks of severe disease in livestock and people in Australia and Malaysia, respectively. HeV repeatedly re-emerges in Australia while NiV continues to cause outbreaks in South Asia (Bangladesh and India), and these viruses have remained transboundary threats. In people and several mammalian species, HeV and NiV infections present as a severe systemic and often fatal neurologic and/or respiratory disease. NiV stands out as a potential pandemic threat because of its associated high case-fatality rates and capacity for human-to-human transmission. The development of effective vaccines, suitable for people and livestock, against HeV and NiV has been a research focus. Here, we review the progress made in NiV and HeV vaccine development, with an emphasis on those approaches that have been tested in established animal challenge models of NiV and HeV infection and disease.
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影响因子：
11.8
作者：
Arunkumar, Govindakarnavar;Devadiga, Santhosha;Nichol, Stuart T.
通讯作者：
Nichol, Stuart T.
影响因子：
5.4
作者：
Bowden, Thomas A.;Crispin, Max;Stuart, David I.
通讯作者：
Stuart, David I.
影响因子：
5.4
作者：
Bishop, Kimberly A.;Stantchev, Tzanko S.;Broder, Christopher C.
通讯作者：
Broder, Christopher C.
影响因子：
3.7
作者：
Bossart, KN;Wang, LF;Broder, CC
通讯作者：
Broder, CC
影响因子：
11.8
作者：
Ching PK;de los Reyes VC;Sucaldito MN;Tayag E;Columna-Vingno AB;Malbas FF Jr;Bolo GC Jr;Sejvar JJ;Eagles D;Playford G;Dueger E;Kaku Y;Morikawa S;Kuroda M;Marsh GA;McCullough S;Foxwell AR
通讯作者：
Foxwell AR