ELASTIC BEHAVIOR OF LUNG IN PATIENTS WITH AIRWAY OBSTRUCTION
ELASTIC BEHAVIOR OF LUNG IN PATIENTS WITH AIRWAY OBSTRUCTION
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DOI：
10.1152/jappl.1969.26.3.330
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发表时间：
1969-01-01
影响因子：
3.3
通讯作者：
COLEBATCH, HJ
中科院分区：
文献类型：
--
作者：
FINUCANE, KE;COLEBATCH, HJ
方法受试者.测量了30名受试者的肺体积和肺的静态机械特性-10名哮喘患者（7名男性，3名女性），10名肺气肿患者（均为男性）和10名健康受试者（均为男性）。哮喘和肺气肿的诊断基于以下标准：哮喘患者出现阵发性呼吸困难和完全可逆的气道阻塞，表现为研究2年内1组用力呼气量（FE&）正常，并且除了过度充气的证据外，胸部X光片正常。所有这些都是在哮喘发作期间进行的研究。肺气肿患者在用力时有持续性呼吸困难和气道阻塞，表现为FE降低和过度充气的放射学证据，以及肺破坏伴中间和周围血管纹理减弱和囊肿形成。对照组运动耐量、胸片、FE&均正常。这些病人由亨利王子医院胸科的工作人员照顾。肺容量。功能残气量（FRC）的测定方法为：在气道阻塞受试者中，通过延长氮气冲洗时间（15-20 min）并辅以周期性过度通气，
METHODSSubjects. Lung volumes and the static mechanical properties of the lung were measured in 30 subjects-10 with asthma (seven males, three females), 10 with emphysema(all males), and 10 healthy subjects (all males). The diagnoses of asthma and of emphysema were based on the following criteria: the patients with asthma had episodic dyspnea and airway obstruction with complete reversibility, indicated by a normal forced expiratory volume at 1 set (FE&) within 2 years of study, and, apart from evidence of overinflation, a normal chest radiograph. All were studied during an attack of asthma. The patients with em physema had persistent dyspnea on exertion and airway obstruction, as indicated by a reduced FE&; and radiographic evidence of overinflation and of lung destruction with attenuation of intermediate and peripheral vascular markings, and cyst formation. The control subjects had a normal exercise tolerance, chest radiograph, and FE&. The patients were in the care of staff members of the Division of Thoracic Medicine, Prince Henry Hospital. Lung volumes. The functional residual capacity (FRC) was measured by prolonged nitrogen washout (15-20 min) assisted by periodic hyperventilation in the subjects with airway obstruction, and by a 7-min washout