Postprandial incorporation of EPA and DHA from transgenic Camelina sativa oil into blood lipids is equivalent to that from fish oil in healthy humans.
Postprandial incorporation of EPA and DHA from transgenic Camelina sativa oil into blood lipids is equivalent to that from fish oil in healthy humans.
复制标题
转基因亚麻荠油中的 EPA 和 DHA 餐后进入血脂的含量与健康人鱼油中的含量相当。
DOI：
10.1017/s0007114519000825
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
West AL
中科院分区：
文献类型：
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作者：
West AL
EPA和DHA是细胞膜的重要组成部分。由于人类合成EPA和DHA的能力有限，这些必须从饮食中获得，主要是从油性鱼类中获得。膳食EPA和DHA的摄入量受到鱼类种群大小和食物选择的限制。来自合成EPA和DHA的转基因植物的种子油代表了这些脂肪酸的潜在替代来源，但尚未在人体中进行过测试。我们假设转基因亚麻荠籽油（CSO）中EPA和DHA进入血脂的含量与鱼油中的含量相当。在一项双盲、餐后交叉试验中，健康男性和女性（18-30岁或50-65岁）在试验餐中食用来自CSO或商业混合鱼油（BFO）的450 mg EPA + DHA。在8小时内，试验油或性别之间EPA和DHA掺入血浆TAG、磷脂酰胆碱或NEFA的情况无显著差异。受试油、年龄组或性别之间餐后VLDL、LDL或HDL大小或浓度无显著差异。在年轻受试者中，两种试验油的餐后血浆TNFα、IL 6或10或可溶性细胞间粘附分子-1浓度无显著差异。这些发现表明，作为CSO摄入的EPA和DHA与BFO相当，并且这种转基因植物油是人体EPA和DHA的合适膳食来源。
EPA and DHA are important components of cell membranes. Since humans have limited ability for EPA and DHA synthesis, these must be obtained from the diet, primarily from oily fish. Dietary EPA and DHA intakes are constrained by the size of fish stocks and by food choice. Seed oil from transgenic plants that synthesise EPA and DHA represents a potential alternative source of these fatty acids, but this has not been tested in humans. We hypothesised that incorporation of EPA and DHA into blood lipids from transgenic Camelina sativa seed oil (CSO) is equivalent to that from fish oil. Healthy men and women (18–30 years or 50–65 years) consumed 450 mg EPA + DHA from either CSO or commercial blended fish oil (BFO) in test meals in a double-blind, postprandial cross-over trial. There were no significant differences between test oils or sexes in EPA and DHA incorporation into plasma TAG, phosphatidylcholine or NEFA over 8 h. There were no significant differences between test oils, age groups or sexes in postprandial VLDL, LDL or HDL sizes or concentrations. There were no significant differences between test oils in postprandial plasma TNFα, IL 6 or 10, or soluble intercellular cell adhesion molecule-1 concentrations in younger participants. These findings show that incorporation into blood lipids of EPA and DHA consumed as CSO was equivalent to BFO and that such transgenic plant oils are a suitable dietary source of EPA and DHA in humans.