INCREASED INCIDENCE OF TYPE-II DIABETES-MELLITUS IN MEXICAN-AMERICANS
INCREASED INCIDENCE OF TYPE-II DIABETES-MELLITUS IN MEXICAN-AMERICANS
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DOI：
10.2337/diacare.14.2.102
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发表时间：
1991-02-01
期刊：
影响因子：
16.2
通讯作者：
STERN, MP
中科院分区：
文献类型：
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作者：
HAFFNER, SM;HAZUDA, HP;STERN, MP
确定墨西哥裔美国人非胰岛素依赖型（II型）糖尿病的发病率是否高于非西班牙裔白人。 目前，还没有研究报告这种疾病在墨西哥裔美国人中的发生率。 研究设计和方法：我们确定了参加圣安东尼奥心脏研究的617名墨西哥裔美国人和306名非西班牙裔白人的8年II型糖尿病发病率，该研究是一项以人群为基础的糖尿病和心血管疾病研究。 40名墨西哥裔美国人（6.5%）和6名非西班牙裔白人（2%）患上了世界卫生组织标准定义的II型糖尿病。 经年龄校正的种族糖尿病发病率比值比（OR;墨西哥裔美国人/非西班牙裔白人）男性为8.13（95%置信区间[C1] 1.10-59.9），女性为3.62（95% CI 1.37-9.55）。 我们调整了年龄，性别，种族，体重指数和教育程度的多元逻辑回归分析。 结果：墨西哥裔美国人的糖尿病发病率继续显示出统计学显著性增加（OR 2.72，95% CI 1.02-7.28）。 肥胖和年龄与糖尿病发病率呈正相关（P < 0.001）。 此外，受试者至少有一些大学教育比那些不到高中教育的糖尿病发病率较低（OR 0.51，95%CI 0.26-0.99）。 结论：墨西哥裔美国人的II型糖尿病发病率高于非西班牙裔白人，这种差异不能用肥胖，年龄或教育程度的种族差异来解释。
To determine whether Mexican Americans have an increased incidence of non-insulin-dependent (type II) diabetes mellitus relative to non-Hispanic whites. Currently, no study has reported on the incidence of this disorder in Mexican Americans. Research Design and Methods: We determined the 8-yr incidence of type II diabetes in 617 Mexican Americans and 306 non-Hispanic whites who participated in the San Antonio Heart Study, a population-based study of diabetes and cardiovascular disease. Forty Mexican Americans (6.5%) and 6 non-Hispanic whites (2%) developed type II diabetes, as defined by World Health Organization criteria. The age-adjusted ethnic odds ratio (OR; Mexican Americans/non-Hispanic whites) for diabetes incidence was 8.13 (95% confidence interval [C1] 1.10-59.9) in men and 3.62 (95% CI 1.37-9.55) in women. We adjusted for age, sex, ethnicity, body mass index, and level of educational attainment with multiple logistic regression analyses. Results: Mexican Americans continued to show a statistically significant increase in diabetes incidence (OR 2.72, 95% CI 1.02-7.28). Obesity and age were also positively related to diabetes incidence in this analysis (P < 0.001). In addition, subjects with at least some college education had a lower incidence of diabetes than those with less than a high school education (OR 0.51, 95% CI 0.26-0.99). Conclusions: The incidence of type II diabetes in Mexican Americans is greater than in non-Hispanic whites, a difference that is not explained by ethnic differences in obesity, age, or level of educational attainment.