Salmonella-induced M-cell formation in germ-free mouse Peyer's patch tissue.
Salmonella-induced M-cell formation in germ-free mouse Peyer's patch tissue.
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沙门氏菌诱导无菌小鼠派尔氏斑组织中 M 细胞的形成。
DOI：
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发表时间：
1991
影响因子：
6
通讯作者：
P. Aldred
中科院分区：
文献类型：
--
作者：
Tor C. Savidge;M. Smith;P. James;P. Aldred
在Peyer‘s斑块组织中存在的M细胞运输肠道抗原，以递送到潜在的淋巴组织，以启动对肠道感染的免疫反应。目前的工作是研究细菌、上皮细胞和免疫细胞之间发生的相互作用如何有助于最初检测和后来消除肠道抗原。无菌小鼠口服感染鼠伤寒沙门氏菌后，7天后M细胞数量、隐窝深度和肠道细胞迁移率增加两到三倍。伴随着这些变化的是滤泡相关上皮组织(FAE)相关的CD4+增加了两倍，FAE相关的CD8+计数减少了三倍。沙门氏菌在感染后不久也增加了M细胞的数量。对隐窝大小和脾重量的其他影响需要更长的时间才能形成。沙门氏菌可能通过改变淋巴滤泡中的局部上皮下免疫环境而产生M细胞。
M cells present in Peyer's patch tissue transport enteric antigens for presentation to underlying lymphoid tissue to initiate immune responses against intestinal infection. Present work investigates how interactions taking place between bacteria, epithelial cells, and immunocytes could contribute to initial detection and later elimination of enteric antigens. Oral infection of germ-free mice with Salmonella typhimurium aroA- caused a twofold to threefold increase in M cell numbers, crypt depth, and enterocyte migration rate after 7 days. These changes were accompanied by a twofold increase in follicle-associated epithelial tissue (FAE)-associated CD4+ and a threefold decrease in FAE-associated CD8+ counts. Salmonella also increased M-cell numbers shortly after infection. Other effects on crypt size and spleen weight took longer to develop. Salmonella probably creates M cells by changing the local subepithelial immune environment in the lymphoid follicle.
新生小鼠中 1 型呼肠孤病毒对肠上皮的粘附和渗透。
影响因子：
29.4
作者：
Wolf,JL;Dambrauskas,R;Sharpe,AH;Trier,JS
通讯作者：
Trier,JS
犬派尔氏斑圆顶上皮的超微结构和碱性磷酸酶活性。
影响因子：
1.8
作者：
HogenEsch,H;Felsburg,PJ
通讯作者：
Felsburg,PJ