Heritability of body composition measured by DXA in the diabetes heart study
Heritability of body composition measured by DXA in the diabetes heart study
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DOI：
10.1038/oby.2005.42
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发表时间：
2005-02-01
期刊：
影响因子：
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通讯作者：
Carr, JJ
中科院分区：
文献类型：
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作者：
Hsu, FC;Lenchik, L;Carr, JJ
目的：本研究的目的是探讨糖尿病心脏研究（DHS）中DXA测量的身体成分的遗传性。研究方法和程序：参与者为来自244个家庭的292名女性和262名男性（年龄38 - 86岁; BMI 17 - 57 kg/m2）。有492对白色和49对非洲裔美国人的兄弟姐妹。DXA测量百分比脂肪质量（FM），全身FM，和瘦体重（LM），以及区域测量躯干脂肪质量（TFM）和apperiallean质量（ALM），获得。使用顺序寡基因连锁分析程序估计FM、LM和BMI的遗传度。结果：在调整了年龄、性别、种族和身高后，各种组成属性的遗传力估计为%FM = 0.64，全身FM = 0.71，TFM = 0.63，全身LM = 0.60，ALM = 0.66，BMI = 0.64（所有p < 0.0001）。对糖尿病状态、吸烟、饮食摄入和体力活动的额外调整仅导致遗传力估计值的微小变化（h（2）= 0.63至0.72，所有p < 0.0001）。此外，全身FM额外校正后的TFM的遗传力是显著的（h（2）= 0.55，p < 0.0001），全身LM额外校正后的ALM的遗传力也是显著的（h（2）= 0. 51，p < 0.讨论：这些数据表明，FM和LM测量DXA是高度遗传的，可以有效地用于设计连锁研究，以定位基因管理机构组成。此外，FM和LM的区域分布可能由遗传决定。
Objective: The purpose of this study was to investigate the heritability of body composition measured by DXA in the Diabetes Heart Study (DHS).Research Methods and Procedures: Participants were 292 women and 262 men (age, 38 to 86 years; BMI, 17 to 57 kg/m(2)) from 244 families. There were 492 white and 49 African-American sibling pairs. DXA measurements of percentage fat mass (FM), whole body FM, and lean mass (LM), as well as regional measurements of trunk fat mass (TFM) and appendicular lean mass (ALM), were obtained. Heritability of FM, LM, and BMI were estimated using Sequential Oligogenic Linkage Analysis Routines.Results: After adjusting for age, gender, ethnicity, and height, the heritability estimates of various compositional attributes were %FM = 0.64, whole body FM = 0.71, TFM = 0.63, whole body LM = 0.60 ALM = 0.66, and BMI = 0.64 (all p < 0.0001). Additional adjustment for diabetes status, smoking, dietary intake, and physical activity resulted in only minor changes in the heritability estimates (h(2) = 0.63 to 0.72, all p < 0.0001). Furthermore, heritability of TFM after additional adjustment for whole body FM was significant (h(2) = 0.55, p < 0.0001), and heritability of ALM after additional adjustment for whole body LM was also significant (h(2) = 0. 5 1, p < 0. 0001).Discussion: These data suggest that FM and LM measured by DXA are highly heritable and can be effectively used in designing linkage studies to locate genes governing body composition. In addition, regional distribution of FM and LM may be genetically determined.