Differences in the amyloid-β-induced inflammatory response in microglia from C57BL/6 and A/J strains of mice
Differences in the amyloid-β-induced inflammatory response in microglia from C57BL/6 and A/J strains of mice
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DOI：
10.1016/j.jneuroim.2004.04.014
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发表时间：
2004-08-01
影响因子：
3.3
通讯作者：
Gervais, F
中科院分区：
文献类型：
--
作者：
Dudal, S;Morissette, C;Gervais, F
分别在低应答株A/J和高应答株C57BL/6小鼠中研究了有或无ifn - γ启动的小胶质细胞对Abeta（1-42）刺激的炎症反应。A/J小胶质细胞在ifn - γ单独或Abeta刺激下表现出中等程度的形态学改变（1-42）。相反，C57BL/6小胶质细胞的细胞形态发生了重大变化，伴随着NO释放的减少和tnf - α产生的显著增加。这些结果表明，小胶质细胞对β的炎症反应程度受遗传因素的强烈影响。小胶质细胞反应调节的个体差异可能是阿尔茨海默病神经病理发展速度的关键因素。(C) 2004 Elsevier B.V.版权所有
The microglial inflammatory response to Abeta(1-42) stimulation with or without IFN-gamma priming was investigated in low and high responder strains of mice, A/J and C57BL/6, respectively. A/J microglia showed moderate morphological changes upon stimulation with IFN-gamma alone or with Abeta(1-42). Conversely, C57BL/6 microglia showed major changes in their cellular morphology, which were accompanied by a decrease in NO release and a marked increase in TNF-alpha production. These results indicate that the magnitude of the microglial inflammatory response to Abeta is strongly influenced by genetic factors. Individual differences in the regulation of the microglial response may be a key player in the rate of development of the neuropathology of AD. (C) 2004 Elsevier B.V. All rights reserved.