Matrix Gla protein is associated with coronary artery calcification as assessed by electron-beam computed tomography
Matrix Gla protein is associated with coronary artery calcification as assessed by electron-beam computed tomography
复制标题
DOI：
10.1160/th03-08-0572
复制
发表时间：
2004-04-01
影响因子：
6.7
通讯作者：
Saito, S
中科院分区：
文献类型：
--
作者：
Jono, S;Ikari, J;Saito, S
基质玻璃蛋白（MGP）是一种具有广泛组织分布的细胞外基质蛋白。研究表明，MGP的表达不仅存在于正常血管中，也存在于钙化的动脉粥样硬化斑块中，并且MGP缺乏的小鼠会发生广泛的动脉钙化。MGP被认为是血管钙化的调节剂。最近的一项临床研究表明MGP基因多态性与心肌梗死风险增加之间存在关联。然而，没有关于血清MGP水平与冠状动脉钙化（CAC）之间关系的报道。我们使用电子束计算机断层扫描（EBCT）评估了CAC的严重程度，并通过酶联免疫吸附法测量了115名疑似冠状动脉疾病患者的血清MGP水平。CAC评分与年龄、性别、高血压、糖尿病、高脂血症、吸烟等传统危险因素相关。冠脉钙化患者血清MGP水平低于无冠脉钙化患者（p400）。我们发现血清MGP水平与CAC的严重程度呈负相关。这些数据表明MGP可能在血管钙化的发展中起作用。
Matrix Gla protein (MGP) is an extracellular matrix protein with wide tissue distribution. It has been demonstrated that the expression of MGP is detected not only in the normal blood vessels but also calcified atherosclerotic plaques, and that MGP deficient mice develop extensive arterial calcification. MGP is thought to be a regulator of vascular calcification. A recent clinical study demonstrates the association between polymorphisms of the MGP gene and increased risk of myocardial infarction. However, there are no reports of the relationship between serum MGP levels and coronary artery calcification (CAC). We evaluated the severity of CAC using electron-beam computed tomography (EBCT), and measured serum MGP levels by enzyme-linked immunosorbent assay in 115 subjects with suspected coronary artery disease. CAC scores were correlated with traditional risk factors, such as age, gender, hypertension, diabetes, hyperlipidemia and smoking. The serum MGP levels were lower in patients with CAC than in those without CAC (p400) coronary calcification, respectively. We found that serum MGP levels are inversely correlated with the severity of CAC. These data suggest a possible role for MGP in the development of vascular calcification.