Direct brain stimulation during episodic memory
Direct brain stimulation during episodic memory
复制标题
DOI：
10.1016/j.cobme.2018.11.004
复制
发表时间：
2018-12-01
影响因子：
3.9
通讯作者：
Rizzuto, Daniel S.
中科院分区：
文献类型：
--
作者：
Ezzyat, Youssef;Rizzuto, Daniel S.
直接脑刺激作为神经系统疾病（如帕金森氏病）的治疗方法的成功已经引起了人们对开发用于其他认知领域（如学习和记忆）的基于刺激的治疗应用的兴趣。在这里，我们回顾了最近的进展，使用刺激的记忆调制和增强人类。已经研究了一组扩展的刺激目标，可以调节广泛的记忆网络和行为表现。在记忆处理过程中使用在线神经解码，闭环系统已被用于以更高的精度提供刺激并改善行为结果。这些数据为未来治疗记忆功能障碍的治疗应用提供了策略。
The success of direct brain stimulation as a treatment for neurological disorders such as Parkinson's Disease has led to increased interest in developing stimulation-based therapeutic applications for other cognitive domains, such as learning and memory. Here, we review recent advances in using stimulation for memory modulation and enhancement in humans. An expanded set of stimulation targets have been studied that can modulate broad memory networks and behavioral performance. Using online neural decoding during memory processing, closed-loop systems have been used to deliver stimulation with greater precision and improve behavioral outcomes. The data suggest strategies for future therapeutic applications to treating memory dysfunction.