The 2020 BMT CTN Myeloma Intergroup Workshop on Immune Profiling and Minimal Residual Disease Testing in Multiple Myeloma.

The 2020 BMT CTN Myeloma Intergroup Workshop on Immune Profiling and Minimal Residual Disease Testing in Multiple Myeloma.
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DOI:
10.1016/j.jtct.2021.05.027
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发表时间:
2021-10
影响因子:
3.2
通讯作者:
McCarthy PL
McCarthy PL
中科院分区:
医学2区
文献类型:
--
作者:
Holstein SA;Bahlis N;Bergsagel PL;Bhutani M;Bolli N;Brownstein C;Demolis P;Foureau D;Gay F;Ghobrial IM;Gormley N;Hillengass J;Kaiser M;Maus MV;Melenhorst JJ;Merz M;Dwyer MO;Paiva B;Pasquini MC;Shah N;Wong SW;Usmani SZ;McCarthy PL

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第五届年度血液和骨髓移植临床试验网络(BMT CTN)关于多发性骨髓瘤免疫分析和微小残留病检测的骨髓瘤小组间研讨会于2020年12月3日星期四作为美国血液学学会年会科学研讨会之一进行。本次研讨会重点讨论了四个主要主题:1)将MRD整合到临床试验设计和实践中; 2)骨髓瘤疾病演变和进展的分子和免疫生物学; 3)下一代测序,下一代流式细胞术和CyTOF技术的适应;以及4)骨髓瘤的嵌合抗原受体T细胞和其他细胞疗法。在本报告中,我们提供了研讨会的演讲摘要,并讨论了该领域的未来发展方向。
The fifth annual Blood and Marrow Transplant Clinical Trials Network (BMT CTN) Myeloma Intergroup Workshop on Immune Profiling and Minimal Residual Disease Testing in Multiple Myeloma was conducted as one of the American Society of Hematology Annual Meeting Scientific Workshops on Thursday December 3, 2020. This workshop focused on four main topics: 1) integrating MRD into clinical trial design and practice; 2) the molecular and immuno-biology of disease evolution and progression in myeloma; 3) adaptation of next generation sequencing, next generation flow cytometry and CyTOF techniques; and 4) chimeric antigen receptor T-cell and other cellular therapies for myeloma. In this report, we provide a summary of the workshop presentations and discuss future directions in the field.
生物标志物的验证以预测癌症免疫疗法的反应:第二卷 - 临床验证和调节考虑。
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