Amelioration of systemic hypertension by converting enzyme inhibition in the renal ablation model.
Amelioration of systemic hypertension by converting enzyme inhibition in the renal ablation model.
复制标题
通过在肾脏消融模型中转化酶抑制来改善系统性高血压。
DOI：
10.1093/ajh/1.2.190
复制
发表时间：
1988
影响因子：
3.2
通讯作者：
Goodman,AI
中科院分区：
文献类型：
--
作者：
Meggs,LG;Garrick,R;Chander,P;Ben-Ari,J;Gammon,D;Goodman,AI
Hypertension associated with a reduction in renal mass has been traditionally thought of as a volume-dependent state. Recent investigations suggest important roles for systemic and glomerular resistance vessels in the pathogenesis of systemic hypertension (SHT) and progression of end-stage renal disease. To examine this relationship, investigations were performed in two groups of rats maintained for 6 weeks following 5/6 renal ablation. Group A received converting enzyme inhibition (CEI) for 6 weeks. Group Β received no treatment. Systolic blood pressure and weight of remnant kidney tissue were both increased in group B (P < 0.01). BUN did not differ in groups A and B; however, renal PGI2excretion was increased in group A (P < 0.01). Renal morphology was preserved in group A, with little or no evidence of glomerular sclerosis.CEI prevents SHT and enhances renal PGI2excretion in this model. The selective increase in PGI2may mediate systemic and renal effects of this agent. Am J Hypertens 1988; 1:190-192
