Anti-proliferative activity of essential oil extracted from Thai medicinal plants on KB and P388 cell lines
Anti-proliferative activity of essential oil extracted from Thai medicinal plants on KB and P388 cell lines
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DOI：
10.1016/j.canlet.2005.04.021
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发表时间：
2006-04-08
期刊：
影响因子：
9.7
通讯作者：
Manosroi, A
中科院分区：
文献类型：
--
作者：
Manosroi, J;Dhumtanom, P;Manosroi, A
采用 MTT 法研究了 17 种泰国药用植物精油对人口腔表皮癌 (KB) 和小鼠白血病 (P388) 细胞系的抗增殖活性。用0.019至4.962 mg/ml不同浓度的油样品处理1 x 10(4)细胞/孔的KB细胞系和1 x 10(5)细胞/孔的P388细胞系。在 KB 细胞系中，番石榴 (Psidium guajava L.) 叶油显示出最高的抗增殖活性，IC50 值为 0.0379 mg/ml（比长春新碱强 4.37 倍），而甜罗勒 (Ocimum basilicum L.) 油显示出最高的抗增殖活性，IC50 值为 0.0362 mg/ml（比长春新碱低 12.7 倍） 5-FU）在 P388 细胞系中。结果证明了泰国药用植物精油治疗癌症的潜力。 (c) 2005 Elsevier Ireland Ltd. 保留所有权利。
Anti-proliferative activity of essential oil from 17 Thai medicinal plants on human mouth epidermal carcinoma (KB) and murine leukemia (P388) cell lines using MTT assay were investigated. An amount of 1 x 10(4) cells/well of KB cell line and 1 x 10(5) cells/well of P388 cell line were treated with the oil samples at different concentrations ranging from 0.019 to 4.962 mg/ml. In KB cell line, Guava (Psidium guajava L.) leaf oil showed the highest anti-proliferative activity with the IC50 value of 0.0379 mg/ml (4.37 times more potent than vincristine) whereas Sweet Basil (Ocimum basilicum L.) oil gave the highest antiproliferative activity with the IC50 value of 0.0362 mg/ml (12.7 times less potent than 5-FU) in P388 cell line. The results demonstrated the potential of essential oil from Thai medicinal plants for cancer treatment. (c) 2005 Elsevier Ireland Ltd. All rights reserved.