Electron absorbed fractions and dose conversion factors for marrow and bone by skeletal regions
Electron absorbed fractions and dose conversion factors for marrow and bone by skeletal regions
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DOI：
10.1097/00004032-200002000-00009
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发表时间：
2000-02-01
期刊：
影响因子：
2.2
通讯作者：
Stabin, MG
中科院分区：
文献类型：
--
作者：
Eckerman, KF;Stabin, MG
可能诱发骨癌和白血病是骨骼照射中主要关注的两种健康影响。在剂量测定评估中要考虑的相关靶组织是骨内膜表面上或附近的细胞（骨肉瘤被认为是由骨内膜表面产生的），以及造血骨髓（与白血病相关）。软组织-骨混合物的复杂几何形状使得计算这些目标区域的吸收剂量成为一个难题。在光子或中子辐射的情况下，带电粒子平衡可能不存在于软组织-骨矿物界面附近。在本文中，开发了吸收分数数据，用于计算沉积在骨小梁内或表面上的电子发射器在目标组织中的剂量。所提出的骨骼平均吸收分数与国际放射防护委员会（ICRP）当代剂量测定公式中使用的该量一致，然后在医学内辐射剂量（MIRD）委员会的计算方案的背景下开发新的骨骼和骨髓模型的实施。描述了与不同年龄个体骨骼不同区域的剂量转换因子（S 值）计算相关的模型参数，并针对定位于骨髓的单克隆抗体进行了示例计算。讨论了这些计算在核医学中辐射剂量计算中的实用性。
The possible inductions of bone cancer and leukemia are the two health effects of primary concern in the irradiation of the skeleton, The relevant target tissues to consider in the dosimetric evaluation have been the cells on or near endosteal surfaces of bone, from which osteosarcomas are thought to arise, and hematopoietic bone marrow, which is associated with leukemia, The complex geometry of the soft tissue-bone intermixture makes calculations of absorbed doses to these target regions a difficult problem. In the case of photon or neutron radiations, charged particle equilibrium may not exist in the vicinity of a soft tissue-bone mineral interface. In this paper, absorbed fraction data are developed for calculations of the dose in the target tissues from electron emitters deposited within the volume or on the surfaces of trabecular bone, The skeletal average absorbed fractions presented are consistent with usage of this quantity in the contemporary dosimetric formulations of the International Commission on Radiological Protection (ICRP), Implementation of the new bone and marrow model is then developed within the context of the calculational schema of the Medical Internal Radiation Dose (MIRD) Committee. Model parameters relevant to the calculation of dose conversion factors (S values) for different regions of the skeleton of individuals of various age are described, and an example calculation is performed for a monoclonal antibody which localizes in the marrow. The utility of these calculations for radiation dose calculations in nuclear medicine is discussed.