Targeted modulation of immune cells and tissues using engineered biomaterials.
Targeted modulation of immune cells and tissues using engineered biomaterials.
复制标题
DOI：
10.1038/s44222-022-00016-2
复制
发表时间：
2023-02-01
期刊：
影响因子：
--
通讯作者：
Irvine, Darrell J
中科院分区：
文献类型：
--
作者：
Yousefpour, Parisa;Ni, Kaiyuan;Irvine, Darrell J
调节免疫系统的疗法为治疗包括传染病、癌症和自身免疫在内的各种疾病提供了前景。生物材料可以促进免疫细胞亚群在外周或淋巴组织中的特异性靶向，并调节刺激的剂量、时间和位置，从而提高疫苗和免疫治疗的安全性和有效性。在这里，我们综述了基于生物材料的策略的最新进展，重点是针对淋巴组织、循环白细胞、组织驻留免疫细胞和疾病部位的免疫细胞。这些方法可以通过提高对不同疾病的免疫力或耐受性来提高免疫疗法的效力和疗效。
Therapies modulating the immune system offer the prospect of treating a wide range of conditions including infectious diseases, cancer and autoimmunity. Biomaterials can promote specific targeting of immune cell subsets in peripheral or lymphoid tissues and modulate the dosage, timing and location of stimulation, thereby improving safety and efficacy of vaccines and immunotherapies. Here we review recent advances in biomaterials-based strategies, focusing on targeting of lymphoid tissues, circulating leukocytes, tissue-resident immune cells and immune cells at disease sites. These approaches can improve the potency and efficacy of immunotherapies by promoting immunity or tolerance against different diseases.