Requirements for growing tissue-engineered vascular grafts
Requirements for growing tissue-engineered vascular grafts
复制标题
DOI：
10.1016/s1054-8807(02)00183-7
复制
发表时间：
2003-03-01
影响因子：
3.7
通讯作者：
Niklason, LE
中科院分区：
文献类型：
--
作者：
Mitchell, SL;Niklason, LE
小直径（<6mm）血管移植物在冠状动脉和外周旁路手术中需求量很大。尽管已经开发了合成移植物，但是可以更好地模拟天然血管的基于组织的血管移植物可能会产生上级结果。基于组织的移植物的成功取决于其满足几个要求的能力。首先，移植物必须具有融合、粘附和静止的内皮以抵抗体内血栓形成。移植物的机械性能必须模拟天然血管的机械性能。因此，移植物必须具有高度组织化的胶原基质以赋予组织强度。最后，移植物必须包含弹性蛋白网络以提供顺应性和回缩。(C)2003年爱思唯尔公司All rights reserved.
Small diameter (< 6 mm) vascular grafts are in large demand for coronary and peripheral bypass procedures. Although synthetic grafts have been developed, tissue-based vascular grafts that can better mimic native vessels will likely yield superior results. The success of a tissue-based graft depends on its ability to meet several requirements. First, a graft must possess a confluent, adherent and quiescent endothelium to resist thrombosis in vivo. The mechanical behavior of the graft must mimic the mechanical properties of a native vessel. Hence, a graft must have a highly organized collagen matrix to impart tissue strength. Finally, a graft must contain an elastin network to provide compliance and recoil. (C) 2003 Elsevier Inc. All rights reserved.